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	ulcerative colitis

Disease ID	177
Disease	ulcerative colitis
Definition	Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Synonym	colitis gravis colitis gravis, nos colitis ulcerative colitis ulcerosa colitis, ulcerative colitis, ulcerative [disease/finding] idiopathic proctocolitis idiopathic proctocolitis (disorder) idiopathic proctocolitis -retired- idiopathic proctocolitis nos idiopathic proctocolitis nos (disorder) inflammatory bowel disease ulcerative colitis inflammatory bowel disease, ulcerative colitis type uc - ulcerative colitis ulcerative colitis (disorder) ulcerative colitis as main diagnosis for the colon ulcerative colitis as reason for lower g.i. examination ulcerative colitis, nos ulcerative colitis, unspecified ulceratve colitis unspcf
DOID	DOID:8577
UMLS	C0009324
MeSH	D003093
SNOMED-CT	SNOMEDCT_US_2016_09_01:64766004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:211) C0009402 \| colorectal cancer \| 39 C0007113 \| rectal cancer \| 39 C0021831 \| bowel disease \| 24 C0021390 \| inflammatory bowel disease \| 21 C0009319 \| colitis \| 20 C0034212 \| pyoderma \| 15 C0085652 \| pyoderma gangrenosum \| 13 C0040053 \| thrombosis \| 13 C0010346 \| crohn's disease \| 13 C0042769 \| virus infection \| 12 C0566602 \| primary sclerosing cholangitis \| 11 C0008313 \| sclerosing cholangitis \| 11 C0007102 \| colon cancer \| 9 C0024299 \| lymphoma \| 8 C0008311 \| cholangitis \| 7 C0042384 \| vasculitis \| 7 C0002871 \| anemia \| 7 C0011991 \| diarrhea \| 6 C0030305 \| pancreatitis \| 6 C0032285 \| pneumonia \| 5 C0343386 \| clostridium difficile infection \| 5 C0034150 \| purpura \| 5 C0039263 \| takayasu arteritis \| 4 C0868908 \| pancolitis \| 4 C0011570 \| depression \| 4 C0020877 \| ileitis \| 4 C0025160 \| megacolon \| 4 C0009402 \| colorectal carcinoma \| 3 C0041296 \| tuberculosis \| 3 C0007113 \| rectal carcinoma \| 3 C0002878 \| haemolytic anaemia \| 3 C0002880 \| autoimmune haemolytic anaemia \| 3 C0037198 \| sinus thrombosis \| 3 C0003864 \| arthritis \| 3 C0027059 \| myocarditis \| 3 C0043117 \| immune thrombocytopenic purpura \| 3 C0011991 \| diarrhoea \| 3 C0241910 \| autoimmune hepatitis \| 2 C0033246 \| proctitis \| 2 C0002871 \| anaemia \| 2 C0242770 \| bronchiolitis obliterans organizing pneumonia \| 2 C0026684 \| appendiceal mucocele \| 2 C0027726 \| nephrotic syndrome \| 2 C0001418 \| adenocarcinoma \| 2 C0027697 \| nephritis \| 2 C0024291 \| hemophagocytic syndrome \| 2 C0007222 \| cardiovascular disease \| 2 C0011849 \| diabetes mellitus \| 2 C0024115 \| lung disease \| 2 C0011847 \| diabetes \| 2 C0206141 \| hypereosinophilic syndrome \| 2 C0013298 \| duodenitis \| 2 C0021390 \| inflammatory bowel diseases \| 2 C0013990 \| emphysema \| 2 C0019829 \| hodgkin's lymphoma \| 2 C0002880 \| autoimmune hemolytic anemia \| 2 C0042164 \| uveitis \| 2 C0042373 \| vascular disease \| 2 C0004030 \| aspergillosis \| 2 C0001339 \| acute pancreatitis \| 2 C0034152 \| henoch-schonlein purpura \| 2 C1704437 \| respiratory distress syndrome \| 2 C0003873 \| rheumatoid arthritis \| 2 C0023895 \| liver disease \| 2 C0002874 \| aplastic anemia \| 2 C0004153 \| atherosclerosis \| 2 C0027707 \| interstitial nephritis \| 2 C0022658 \| nephropathy \| 2 C0037274 \| dermatosis \| 2 C0856761 \| budd-chiari syndrome \| 2 C0002878 \| hemolytic anemia \| 2 C0025162 \| toxic megacolon \| 2 C0035222 \| acute respiratory distress syndrome \| 2 C0006271 \| bronchiolitis \| 2 C0151436 \| leukocytoclastic vasculitis \| 2 C0021053 \| immune disease \| 2 C0024314 \| lymphoproliferative disorder \| 1 C0027051 \| myocardial infarct \| 1 C0155773 \| portal vein thrombosis \| 1 C0018784 \| sensorineural hearing loss \| 1 C0037274 \| skin disease \| 1 C0410422 \| chronic recurrent multifocal osteomyelitis \| 1 C0004623 \| bacterial infections \| 1 C0272412 \| splenic abscess \| 1 C0004352 \| infantile autism \| 1 C0002438 \| amebiasis \| 1 C0032305 \| pneumocystis \| 1 C0035333 \| retinitis \| 1 C0242379 \| lung cancer \| 1 C0007137 \| squamous cell carcinoma \| 1 C0013370 \| intestinal amebiasis \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0341335 \| cmv colitis \| 1 C0079731 \| b-cell lymphoma \| 1 C0018920 \| cavernous haemangioma \| 1 C0026769 \| multiple sclerosis \| 1 C0008312 \| biliary cirrhosis \| 1 C0038220 \| status epilepticus \| 1 C0949690 \| spondyloarthritis \| 1 C0021845 \| bowel perforation \| 1 C0004352 \| autism \| 1 C0007177 \| pericardial tamponade \| 1 C0023470 \| myelogenous leukemia \| 1 C0032453 \| relapsing polychondritis \| 1 C0023269 \| leiomyosarcoma \| 1 C0087086 \| thrombi \| 1 C0040053 \| thrombus \| 1 C0036421 \| systemic sclerosis \| 1 C0037280 \| infestation \| 1 C0022116 \| ischemia \| 1 C0023267 \| fibroid \| 1 C0154841 \| central retinal vein occlusion \| 1 C0030809 \| pemphigus vulgaris \| 1 C0016412 \| folate deficiency \| 1 C0022893 \| labyrinthitis \| 1 C0021843 \| bowel obstruction \| 1 C0021933 \| intussusception \| 1 C0019112 \| hemorrhoids \| 1 C0042870 \| vitamin d deficiency \| 1 C0003467 \| anxiety \| 1 C0014118 \| endocarditis \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0018203 \| chronic granulomatous disease \| 1 C0018916 \| haemangioma \| 1 C0242647 \| malt lymphoma \| 1 C0149640 \| carcinoma of the cecum \| 1 C0030326 \| panniculitis \| 1 C0341335 \| cytomegalovirus colitis \| 1 C0007785 \| cerebral infarct \| 1 C1261473 \| sarcoma \| 1 C0036203 \| cutaneous sarcoid \| 1 C0153446 \| anal cancer \| 1 C0024314 \| lymphoproliferative disease \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0740277 \| bile duct cancer \| 1 C1527407 \| eosinophilic pneumonia \| 1 C0011633 \| dermatomyositis \| 1 C0595978 \| idiopathic megacolon \| 1 C0006272 \| bronchiolitis obliterans \| 1 C0023281 \| leishmaniasis \| 1 C0019202 \| wilson's disease \| 1 C0036454 \| visual field defect \| 1 C0023418 \| leukemia \| 1 C0027121 \| myositis \| 1 C0023283 \| cutaneous leishmaniasis \| 1 C0036220 \| kaposi's sarcoma \| 1 C0008513 \| chorioretinitis \| 1 C0024291 \| haemophagocytic lymphohistiocytosis \| 1 C0238003 \| appendiceal adenocarcinoma \| 1 C0004943 \| behcet's disease \| 1 C0017152 \| gastritis \| 1 C0042165 \| anterior uveitis \| 1 C0206062 \| interstitial lung disease \| 1 C0009402 \| colorectal carcinomas \| 1 C0007785 \| cerebral infarction \| 1 C2697932 \| loeys-dietz syndrome \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0010068 \| coronary artery disease \| 1 C1527249 \| colorectal cancers \| 1 C0007642 \| cellulitis \| 1 C0206178 \| cmv retinitis \| 1 C0024623 \| gastric cancer \| 1 C0027051 \| myocardial infarction \| 1 C0039446 \| telangiectasis \| 1 C0017661 \| iga nephropathy \| 1 C0029443 \| osteomyelitis \| 1 C0018552 \| hamartoma \| 1 C0155626 \| acute mi \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0004096 \| asthma \| 1 C0032266 \| pneumatosis cystoides intestinalis \| 1 C0040034 \| thrombocytopenia \| 1 C0039263 \| takayasu disease \| 1 C0267572 \| ulcerative proctitis \| 1 C0008350 \| gallstones \| 1 C0023473 \| chronic myelogenous leukemia \| 1 C0030807 \| pemphigus \| 1 C0003615 \| appendicitis \| 1 C0017658 \| glomerulonephritis \| 1 C1276146 \| cutaneous lymphoma \| 1 C0042870 \| vitamin d defic \| 1 C0030805 \| pemphigoid \| 1 C0004623 \| bacterial infection \| 1 C0079744 \| diffuse large b-cell lymphoma \| 1 C0022951 \| lactose intolerance \| 1 C0014038 \| encephalitis \| 1 C0007177 \| cardiac tamponade \| 1 C0036202 \| sarcoidosis \| 1 C0014121 \| infective endocarditis \| 1 C0085113 \| neurofibromatosis \| 1 C0156147 \| crohn's colitis \| 1 C0238106 \| clostridium difficile colitis \| 1 C0338575 \| sagittal sinus thrombosis \| 1 C0007787 \| transient ischemic attack \| 1 C0001430 \| adenoma \| 1 C0149521 \| chronic pancreatitis \| 1 C0037274 \| dermatological disorder \| 1 C0039263 \| takayasu's disease \| 1 C0021345 \| mononucleosis \| 1 C0037998 \| splenic infarction \| 1 C0035328 \| retinal vein occlusion \| 1 C0020502 \| hyperparathyroidism \| 1 C0949691 \| spondyloarthropathy \| 1 C0002726 \| amyloidosis \| 1 C0019158 \| hepatitis \| 1 C0034885 \| rectal neoplasms \| 1 C0019829 \| hodgkin lymphoma \| 1 C0700101 \| carcinoma of the urethra \| 1 C1527336 \| sjogren's syndrome \| 1 C0036203 \| cutaneous sarcoidosis \| 1 C0155686 \| acute myocarditis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:92) 3123 \| HLA-DRB1 \| CTD_human 8624 \| PSMG1 \| CTD_human 7124 \| TNF \| CTD_human 3553 \| IL1B \| CTD_human 5970 \| RELA \| CTD_human 3117 \| HLA-DQA1 \| GWASCAT 5771 \| PTPN2 \| CTD_human 6774 \| STAT3 \| CTD_human 4790 \| NFKB1 \| GWASCAT 3717 \| JAK2 \| CTD_human 149233 \| IL23R \| CTD_human;GWASCAT;UNIPROT 1001 \| CDH3 \| CTD_human 3593 \| IL12B \| CTD_human 8877 \| SPHK1 \| CTD_human 23252 \| OTUD3 \| GWASCAT 1670 \| DEFA5 \| CTD_human 150962 \| PUS10 \| GWASCAT 10320 \| IKZF1 \| CTD_human 7412 \| VCAM1 \| CTD_human 1893 \| ECM1 \| CTD_human 51750 \| RTEL1 \| GWASCAT 1811 \| SLC26A3 \| CTD_human 4318 \| MMP9 \| CTD_human 2212 \| FCGR2A \| CTD_human;GWASCAT 219771 \| CCNY \| CTD_human;GWASCAT 3383 \| ICAM1 \| CTD_human 84441 \| MAML2 \| GWASCAT 64127 \| NOD2 \| CTD_human;UNIPROT 9966 \| TNFSF15 \| CTD_human;GWASCAT 3663 \| IRF5 \| CTD_human 646982 \| LINC00598 \| GWASCAT 5788 \| PTPRC \| GWASCAT 3586 \| IL10 \| CTD_human;GWASCAT 3576 \| CXCL8 \| CTD_human 629 \| CFB \| GWASCAT 8209 \| C21orf33 \| GWASCAT 999 \| CDH1 \| CTD_human 4584 \| MUC3A \| CTD_human;UNIPROT 3172 \| HNF4A \| CTD_human 8767 \| RIPK2 \| CTD_human 51460 \| SFMBT1 \| GWASCAT 1235 \| CCR6 \| CTD_human 3683 \| ITGAL \| GWASCAT 4353 \| MPO \| CTD_human 7850 \| IL1R2 \| CTD_human 55801 \| IL26 \| GWASCAT 6556 \| SLC11A1 \| CTD_human 159296 \| NKX2-3 \| CTD_human;GWASCAT 5739 \| PTGIR \| GWASCAT 8927 \| BSN \| GWASCAT 55765 \| C1orf106 \| GWASCAT 3912 \| LAMB1 \| CTD_human 64170 \| CARD9 \| CTD_human;GWASCAT 100533107 \| RTEL1-TNFRSF6B \| GWASCAT 639 \| PRDM1 \| CTD_human 4485 \| MST1 \| CTD_human;GWASCAT 11315 \| PARK7 \| GWASCAT 11261 \| CHP1 \| GWASCAT 345611 \| IRGM \| CTD_human 120400 \| NXPE1 \| GWASCAT 201266 \| SLC39A11 \| GWASCAT 146198 \| ZFP90 \| GWASCAT 836 \| CASP3 \| CTD_human 23308 \| ICOSLG \| CTD_human 3575 \| IL7R \| CTD_human;GWASCAT 8924 \| HERC2 \| CTD_human 10747 \| MASP2 \| CTD_human 101927324 \| LINC01475 \| GWASCAT 51738 \| GHRL \| CTD_human 5334 \| PLCL1 \| GWASCAT 100996485 \| C5orf66 \| GWASCAT 4046 \| LSP1 \| CTD_human;GWASCAT 4057 \| LTF \| CTD_human 23046 \| KIF21B \| CTD_human 94103 \| ORMDL3 \| CTD_human 3579 \| CXCR2 \| CTD_human 3577 \| CXCR1 \| CTD_human 327 \| APEH \| GWASCAT 6364 \| CCL20 \| CTD_human 8807 \| IL18RAP \| CTD_human 10544 \| PROCR \| GWASCAT 400935 \| IL17REL \| CTD_human;GWASCAT 10109 \| ARPC2 \| CTD_human 647215 \| MROH3P \| GWASCAT 1671 \| DEFA6 \| CTD_human 54535 \| CCHCR1 \| GWASCAT 55876 \| GSDMB \| GWASCAT 2768 \| GNA12 \| CTD_human;GWASCAT 132612 \| ADAD1 \| GWASCAT 54546 \| RNF186 \| GWASCAT 1611 \| DAP \| CTD_human;GWASCAT 2494 \| NR5A2 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:179) 132612 \| ADAD1 \| CIPHER 177 \| AGER \| CIPHER 327 \| APEH \| CIPHER 348 \| APOE \| CIPHER 8927 \| BSN \| CIPHER 56244 \| BTNL2 \| CIPHER 55765 \| C1orf106 \| CIPHER 8209 \| C21orf33 \| CIPHER 64170 \| CARD9 \| CIPHER;CTD_human 54535 \| CCHCR1 \| CIPHER 219771 \| CCNY \| CIPHER;CTD_human 4261 \| CIITA \| CIPHER 1192 \| CLIC1 \| CIPHER 57511 \| COG6 \| CIPHER 1493 \| CTLA4 \| CIPHER 3579 \| CXCR2 \| CIPHER;CTD_human 1535 \| CYBA \| CIPHER 1601 \| DAB2 \| CIPHER 1611 \| DAP \| CIPHER;CTD_human 2212 \| FCGR2A \| CIPHER;CTD_human 2768 \| GNA12 \| CIPHER;CTD_human 2805 \| GOT1 \| CIPHER 2835 \| GPR12 \| CIPHER 2859 \| GPR35 \| CIPHER 63940 \| GPSM3 \| CIPHER 55876 \| GSDMB \| CIPHER 3123 \| HLA-DRB1 \| CIPHER;CTD_human 3132 \| HLA-DRB9 \| CIPHER 3172 \| HNF4A \| CIPHER;CTD_human 3586 \| IL10 \| CIPHER;CTD_human 3593 \| IL12B \| CIPHER;CTD_human 3605 \| IL17A \| CIPHER 112744 \| IL17F \| CIPHER 400935 \| IL17REL \| CIPHER;CTD_human 7850 \| IL1R2 \| CIPHER;CTD_human 149233 \| IL23R \| CIPHER;CTD_human 55801 \| IL26 \| CIPHER 3575 \| IL7R \| CIPHER;CTD_human 11172 \| INSL6 \| CIPHER 3394 \| IRF8 \| CIPHER 375616 \| KCP \| CIPHER 3912 \| LAMB1 \| CIPHER;CTD_human 4046 \| LSP1 \| CIPHER;CTD_human 4277 \| MICB \| CIPHER 4282 \| MIF \| CIPHER 4292 \| MLH1 \| CIPHER 4485 \| MST1 \| CIPHER;CTD_human 4524 \| MTHFR \| CIPHER 4548 \| MTR \| CIPHER 4552 \| MTRR \| CIPHER 9 \| NAT1 \| CIPHER 4780 \| NFE2L2 \| CIPHER 159296 \| NKX2-3 \| CIPHER;CTD_human 10392 \| NOD1 \| CIPHER 4855 \| NOTCH4 \| CIPHER 1728 \| NQO1 \| CIPHER 8204 \| NRIP1 \| CIPHER 167826 \| OLIG3 \| CIPHER 23252 \| OTUD3 \| CIPHER 11315 \| PARK7 \| CIPHER 5089 \| PBX2 \| CIPHER 5307 \| PITX1 \| CIPHER 5468 \| PPARG \| CIPHER 150962 \| PUS10 \| CIPHER 10171 \| RCL1 \| CIPHER 54546 \| RNF186 \| CIPHER 728010 \| RPL35P3 \| CIPHER 100271520 \| RPL39P28 \| CIPHER 100271063 \| RPS14P1 \| CIPHER 442426 \| RPS2P34 \| CIPHER 51750 \| RTEL1 \| CIPHER 23314 \| SATB2 \| CIPHER 1811 \| SLC26A3 \| CIPHER;CTD_human 6550 \| SLC9A3 \| CIPHER 57154 \| SMURF1 \| CIPHER 6648 \| SOD2 \| CIPHER 6948 \| TCN2 \| CIPHER 7040 \| TGFB1 \| CIPHER 7124 \| TNF \| CIPHER;CTD_human 8764 \| TNFRSF14 \| CIPHER 8771 \| TNFRSF6B \| CIPHER 9966 \| TNFSF15 \| CIPHER;CTD_human 7421 \| VDR \| CIPHER 7422 \| VEGFA \| CIPHER 54361 \| WNT4 \| CIPHER 146198 \| ZFP90 \| CIPHER 124626 \| ZPBP2 \| CIPHER 5243 \| ABCB1 \| CIPHER 10109 \| ARPC2 \| CIPHER;CTD_human 253559 \| CADM2 \| CIPHER 6356 \| CCL11 \| CIPHER 6369 \| CCL24 \| CIPHER 10344 \| CCL26 \| CIPHER 929 \| CD14 \| CIPHER 999 \| CDH1 \| CIPHER;CTD_human 54901 \| CDKAL1 \| CIPHER 55722 \| CEP72 \| CIPHER 1738 \| DLD \| CIPHER 1893 \| ECM1 \| CIPHER;CTD_human 9103 \| FCGR2C \| CIPHER 8522 \| GAS7 \| CIPHER 9340 \| GLP2R \| CIPHER 2961 \| GTF2E2 \| CIPHER 3107 \| HLA-C \| CIPHER 3117 \| HLA-DQA1 \| CIPHER 3119 \| HLA-DQB1 \| CIPHER 3122 \| HLA-DRA \| CIPHER 3127 \| HLA-DRB5 \| CIPHER 3176 \| HNMT \| CIPHER 10410 \| IFITM3 \| CIPHER 3458 \| IFNG \| CIPHER 3589 \| IL11 \| CIPHER 29949 \| IL19 \| CIPHER 3553 \| IL1B \| CIPHER;CTD_human 3554 \| IL1R1 \| CIPHER 3557 \| IL1RN \| CIPHER 50616 \| IL22 \| CIPHER 3565 \| IL4 \| CIPHER 3641 \| INSL4 \| CIPHER 3717 \| JAK2 \| CIPHER;CTD_human 23046 \| KIF21B \| CIPHER;CTD_human 3803 \| KIR2DL2 \| CIPHER 3804 \| KIR2DL3 \| CIPHER 100132285 \| KIR2DS2 \| CIPHER 8302 \| KLRC4 \| CIPHER 402569 \| KPNA7 \| CIPHER 4210 \| MEFV \| CIPHER 100507436 \| MICA \| CIPHER 4312 \| MMP1 \| CIPHER 4314 \| MMP3 \| CIPHER 4584 \| MUC3A \| CIPHER;CTD_human 4790 \| NFKB1 \| CIPHER 4795 \| NFKBIL1 \| CIPHER 4842 \| NOS1 \| CIPHER 94103 \| ORMDL3 \| CIPHER;CTD_human 30814 \| PLA2G2E \| CIPHER 7941 \| PLA2G7 \| CIPHER 5771 \| PTPN2 \| CIPHER;CTD_human 5966 \| REL \| CIPHER 170591 \| S100Z \| CIPHER 6583 \| SLC22A4 \| CIPHER 6584 \| SLC22A5 \| CIPHER 6774 \| STAT3 \| CIPHER;CTD_human 6778 \| STAT6 \| CIPHER 7097 \| TLR2 \| CIPHER 7099 \| TLR4 \| CIPHER 7157 \| TP53 \| CIPHER 7172 \| TPMT \| CIPHER 11076 \| TPPP \| CIPHER 219333 \| USP12 \| CIPHER 8877 \| SPHK1 \| CTD_human 10320 \| IKZF1 \| CTD_human 4318 \| MMP9 \| CTD_human 7412 \| VCAM1 \| CTD_human 1001 \| CDH3 \| CTD_human 639 \| PRDM1 \| CTD_human 100529151 \| IBD11 \| CTD_human 8624 \| PSMG1 \| CTD_human 23308 \| ICOSLG \| CTD_human 836 \| CASP3 \| CTD_human 8924 \| HERC2 \| CTD_human 10747 \| MASP2 \| CTD_human 4353 \| MPO \| CTD_human 64127 \| NOD2 \| CTD_human 3576 \| CXCL8 \| CTD_human 8767 \| RIPK2 \| CTD_human 3577 \| CXCR1 \| CTD_human 51738 \| GHRL \| CTD_human 6364 \| CCL20 \| CTD_human 5970 \| RELA \| CTD_human 8807 \| IL18RAP \| CTD_human 345611 \| IRGM \| CTD_human 1671 \| DEFA6 \| CTD_human 1670 \| DEFA5 \| CTD_human 6556 \| SLC11A1 \| CTD_human 1235 \| CCR6 \| CTD_human 3383 \| ICAM1 \| CTD_human 3663 \| IRF5 \| CTD_human 4057 \| LTF \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:333) 2 \| A2M \| 1.026 \| DISEASES 11194 \| ABCB8 \| 1.079 \| DISEASES 10257 \| ABCC4 \| 1.145 \| DISEASES 65057 \| ACD \| 2.192 \| DISEASES 60 \| ACTB \| 1.018 \| DISEASES 11085 \| ADAM30 \| 1.339 \| DISEASES 111 \| ADCY5 \| 4.072 \| DISEASES 9370 \| ADIPOQ \| 1.02 \| DISEASES 240 \| ALOX5 \| 1.031 \| DISEASES 23600 \| AMACR \| 1.125 \| DISEASES 408 \| ARRB1 \| 1.251 \| DISEASES 56624 \| ASAH2 \| 1.636 \| DISEASES 55054 \| ATG16L1 \| 5.233 \| DISEASES 567 \| B2M \| 1.605 \| DISEASES 22893 \| BAHD1 \| 1.801 \| DISEASES 11177 \| BAZ1A \| 1.101 \| DISEASES 266675 \| BEST4 \| 1.036 \| DISEASES 632 \| BGLAP \| 2.209 \| DISEASES 552900 \| BOLA2 \| 1.367 \| DISEASES 54014 \| BRWD1 \| 1.719 \| DISEASES 682 \| BSG \| 1.195 \| DISEASES 56244 \| BTNL2 \| 2.036 \| DISEASES 256815 \| C10orf67 \| 1.864 \| DISEASES 55765 \| C1orf106 \| 1.658 \| DISEASES 79012 \| CAMKV \| 2.875 \| DISEASES 22900 \| CARD8 \| 2.236 \| DISEASES 64170 \| CARD9 \| 2.44 \| DISEASES 834 \| CASP1 \| 2.48 \| DISEASES 80125 \| CCDC33 \| 1.226 \| DISEASES 6364 \| CCL20 \| 2.916 \| DISEASES 6370 \| CCL25 \| 3.099 \| DISEASES 388372 \| CCL4L1 \| 1.636 \| DISEASES 9560 \| CCL4L2 \| 1.328 \| DISEASES 6354 \| CCL7 \| 1.573 \| DISEASES 6355 \| CCL8 \| 1.34 \| DISEASES 219771 \| CCNY \| 2.563 \| DISEASES 1232 \| CCR3 \| 1.499 \| DISEASES 10803 \| CCR9 \| 3.664 \| DISEASES 51622 \| CCZ1 \| 2.066 \| DISEASES 9332 \| CD163 \| 1.755 \| DISEASES 930 \| CD19 \| 2.328 \| DISEASES 910 \| CD1B \| 2.567 \| DISEASES 911 \| CD1C \| 2.462 \| DISEASES 912 \| CD1D \| 1.901 \| DISEASES 914 \| CD2 \| 2.795 \| DISEASES 958 \| CD40 \| 2.607 \| DISEASES 959 \| CD40LG \| 3.838 \| DISEASES 960 \| CD44 \| 2.274 \| DISEASES 921 \| CD5 \| 1.69 \| DISEASES 9308 \| CD83 \| 1.818 \| DISEASES 942 \| CD86 \| 2.571 \| DISEASES 1029 \| CDKN2A \| 1.911 \| DISEASES 1045 \| CDX2 \| 1.877 \| DISEASES 2491 \| CENPI \| 1.149 \| DISEASES 629 \| CFB \| 1.456 \| DISEASES 1103 \| CHAT \| 1.427 \| DISEASES 1137 \| CHRNA4 \| 1.252 \| DISEASES 23562 \| CLDN14 \| 1.708 \| DISEASES 9075 \| CLDN2 \| 3.991 \| DISEASES 1365 \| CLDN3 \| 1.907 \| DISEASES 1364 \| CLDN4 \| 2.09 \| DISEASES 7122 \| CLDN5 \| 1.18 \| DISEASES 1380 \| CR2 \| 1.022 \| DISEASES 1394 \| CRHR1 \| 1.378 \| DISEASES 1490 \| CTGF \| 1.547 \| DISEASES 1499 \| CTNNB1 \| 3.054 \| DISEASES 50624 \| CUZD1 \| 1.905 \| DISEASES 1524 \| CX3CR1 \| 1.418 \| DISEASES 2919 \| CXCL1 \| 2.642 \| DISEASES 6387 \| CXCL12 \| 1.528 \| DISEASES 2920 \| CXCL2 \| 1.959 \| DISEASES 4283 \| CXCL9 \| 2.284 \| DISEASES 2833 \| CXCR3 \| 2.809 \| DISEASES 7852 \| CXCR4 \| 1.084 \| DISEASES 1555 \| CYP2B6 \| 1.066 \| DISEASES 1576 \| CYP3A4 \| 1.575 \| DISEASES 51428 \| DDX41 \| 1.989 \| DISEASES 1668 \| DEFA3 \| 1.589 \| DISEASES 1670 \| DEFA5 \| 3.16 \| DISEASES 414325 \| DEFB103A \| 1.942 \| DISEASES 55894 \| DEFB103B \| 1.942 \| DISEASES 140596 \| DEFB104A \| 1.904 \| DISEASES 503618 \| DEFB104B \| 1.905 \| DISEASES 9231 \| DLG5 \| 4.505 \| DISEASES 1755 \| DMBT1 \| 1.833 \| DISEASES 25822 \| DNAJB5 \| 1.632 \| DISEASES 1785 \| DNM2 \| 1.949 \| DISEASES 1791 \| DNTT \| 1.697 \| DISEASES 1893 \| ECM1 \| 2.751 \| DISEASES 374786 \| EFCAB5 \| 1.465 \| DISEASES 10938 \| EHD1 \| 1.258 \| DISEASES 1995 \| ELAVL3 \| 1.514 \| DISEASES 1999 \| ELF3 \| 1.635 \| DISEASES 339221 \| ENPP7 \| 2.11 \| DISEASES 953 \| ENTPD1 \| 1.233 \| DISEASES 2058 \| EPRS \| 1.044 \| DISEASES 64167 \| ERAP2 \| 1.062 \| DISEASES 2070 \| EYA4 \| 1.975 \| DISEASES 2152 \| F3 \| 1.516 \| DISEASES 63939 \| FAM217B \| 2.546 \| DISEASES 441168 \| FAM26F \| 1.789 \| DISEASES 339145 \| FAM92B \| 2.692 \| DISEASES 355 \| FAS \| 1.843 \| DISEASES 356 \| FASLG \| 2.247 \| DISEASES 2209 \| FCGR1A \| 1.704 \| DISEASES 2214 \| FCGR3A \| 2.726 \| DISEASES 2272 \| FHIT \| 1.119 \| DISEASES 10211 \| FLOT1 \| 1.361 \| DISEASES 50943 \| FOXP3 \| 3.701 \| DISEASES 2524 \| FUT2 \| 1.769 \| DISEASES 2526 \| FUT4 \| 2.04 \| DISEASES 2530 \| FUT8 \| 1.474 \| DISEASES 7855 \| FZD5 \| 1.569 \| DISEASES 2520 \| GAST \| 1.133 \| DISEASES 2625 \| GATA3 \| 2.574 \| DISEASES 2641 \| GCG \| 1.041 \| DISEASES 51738 \| GHRL \| 1.207 \| DISEASES 2813 \| GP2 \| 3.521 \| DISEASES 2835 \| GPR12 \| 1.284 \| DISEASES 2859 \| GPR35 \| 1.441 \| DISEASES 55876 \| GSDMB \| 1.902 \| DISEASES 2980 \| GUCA2A \| 2 \| DISEASES 2981 \| GUCA2B \| 1.786 \| DISEASES 727936 \| GXYLT2 \| 1.958 \| DISEASES 3039 \| HBA1 \| 1.4 \| DISEASES 51696 \| HECA \| 1.534 \| DISEASES 3105 \| HLA-A \| 1.88 \| DISEASES 3106 \| HLA-B \| 2.116 \| DISEASES 3117 \| HLA-DQA1 \| 1.046 \| DISEASES 3122 \| HLA-DRA \| 2.077 \| DISEASES 3123 \| HLA-DRB1 \| 2.923 \| DISEASES 3127 \| HLA-DRB5 \| 1.342 \| DISEASES 3146 \| HMGB1 \| 1.225 \| DISEASES 3174 \| HNF4G \| 1.982 \| DISEASES 3240 \| HP \| 2.183 \| DISEASES 3298 \| HSF2 \| 1.571 \| DISEASES 3329 \| HSPD1 \| 1.618 \| DISEASES 3384 \| ICAM2 \| 2.024 \| DISEASES 23308 \| ICOSLG \| 1.377 \| DISEASES 414328 \| IDNK \| 1.502 \| DISEASES 3430 \| IFI35 \| 1.734 \| DISEASES 8519 \| IFITM1 \| 1.697 \| DISEASES 10410 \| IFITM3 \| 2.272 \| DISEASES 3456 \| IFNB1 \| 1.968 \| DISEASES 100885789 \| IFNG-AS1 \| 1.889 \| DISEASES 7866 \| IFRD2 \| 1.33 \| DISEASES 3476 \| IGBP1 \| 1.461 \| DISEASES 3586 \| IL10 \| 5.04 \| DISEASES 3605 \| IL17A \| 4.72 \| DISEASES 112744 \| IL17F \| 3.054 \| DISEASES 23765 \| IL17RA \| 1.135 \| DISEASES 400935 \| IL17REL \| 2.862 \| DISEASES 29949 \| IL19 \| 1.813 \| DISEASES 7850 \| IL1R2 \| 2.435 \| DISEASES 53833 \| IL20RB \| 1.335 \| DISEASES 50616 \| IL22 \| 3.441 \| DISEASES 149233 \| IL23R \| 5.236 \| DISEASES 246778 \| IL27 \| 1.009 \| DISEASES 3559 \| IL2RA \| 2.548 \| DISEASES 9235 \| IL32 \| 1.626 \| DISEASES 90865 \| IL33 \| 2.951 \| DISEASES 3563 \| IL3RA \| 1.075 \| DISEASES 3572 \| IL6ST \| 1.234 \| DISEASES 3654 \| IRAK1 \| 1.3 \| DISEASES 3663 \| IRF5 \| 2.216 \| DISEASES 345611 \| IRGM \| 4.545 \| DISEASES 3683 \| ITGAL \| 2.423 \| DISEASES 3684 \| ITGAM \| 3.094 \| DISEASES 9445 \| ITM2B \| 3.127 \| DISEASES 3704 \| ITPA \| 2.022 \| DISEASES 3716 \| JAK1 \| 1.197 \| DISEASES 3717 \| JAK2 \| 2.053 \| DISEASES 3718 \| JAK3 \| 1.825 \| DISEASES 3725 \| JUN \| 1.535 \| DISEASES 10656 \| KHDRBS3 \| 1.303 \| DISEASES 57710 \| KIAA1614 \| 2.184 \| DISEASES 3803 \| KIR2DL2 \| 1.03 \| DISEASES 3804 \| KIR2DL3 \| 1.063 \| DISEASES 100287879 \| LINC00994 \| 2.425 \| DISEASES 348120 \| LINC01193 \| 1.567 \| DISEASES 100505591 \| LRRC3C \| 2.438 \| DISEASES 4049 \| LTA \| 2.169 \| DISEASES 4050 \| LTB \| 1.573 \| DISEASES 9863 \| MAGI2 \| 2.52 \| DISEASES 5599 \| MAPK8 \| 1.637 \| DISEASES 153562 \| MARVELD2 \| 1.227 \| DISEASES 23101 \| MCF2L2 \| 1.144 \| DISEASES 100507436 \| MICA \| 3.234 \| DISEASES 84299 \| MIEN1 \| 1.448 \| DISEASES 4295 \| MLN \| 2.021 \| DISEASES 221938 \| MMD2 \| 1.142 \| DISEASES 4312 \| MMP1 \| 2.296 \| DISEASES 4318 \| MMP9 \| 2.632 \| DISEASES 79710 \| MORC4 \| 1.373 \| DISEASES 729967 \| MORN2 \| 1.399 \| DISEASES 4485 \| MST1 \| 2.769 \| DISEASES 4524 \| MTHFR \| 2.154 \| DISEASES 4582 \| MUC1 \| 1.561 \| DISEASES 10071 \| MUC12 \| 1.984 \| DISEASES 283463 \| MUC19 \| 1.723 \| DISEASES 4583 \| MUC2 \| 4.035 \| DISEASES 4584 \| MUC3A \| 1.828 \| DISEASES 4585 \| MUC4 \| 1.986 \| DISEASES 4586 \| MUC5AC \| 1.724 \| DISEASES 727897 \| MUC5B \| 1.651 \| DISEASES 4588 \| MUC6 \| 1.352 \| DISEASES 4609 \| MYC \| 1.544 \| DISEASES 4615 \| MYD88 \| 2.286 \| DISEASES 4638 \| MYLK \| 2.129 \| DISEASES 4650 \| MYO9B \| 3.851 \| DISEASES 9 \| NAT1 \| 1.173 \| DISEASES 4689 \| NCF4 \| 2.014 \| DISEASES 65009 \| NDRG4 \| 1.706 \| DISEASES 4745 \| NELL1 \| 1.186 \| DISEASES 4795 \| NFKBIL1 \| 2.437 \| DISEASES 64332 \| NFKBIZ \| 1.597 \| DISEASES 56954 \| NIT2 \| 1.159 \| DISEASES 159296 \| NKX2-3 \| 4.376 \| DISEASES 114548 \| NLRP3 \| 2.188 \| DISEASES 4843 \| NOS2 \| 2.63 \| DISEASES 27035 \| NOX1 \| 1.474 \| DISEASES 594857 \| NPS \| 2.783 \| DISEASES 8856 \| NR1I2 \| 2.938 \| DISEASES 100506658 \| OCLN \| 3.612 \| DISEASES 81696 \| OR5V1 \| 2.467 \| DISEASES 23252 \| OTUD3 \| 2.066 \| DISEASES 54726 \| OTUD4 \| 1.461 \| DISEASES 5016 \| OVGP1 \| 1.384 \| DISEASES 164091 \| PAQR7 \| 1.62 \| DISEASES 56288 \| PARD3 \| 2.214 \| DISEASES 59351 \| PBOV1 \| 2.623 \| DISEASES 246330 \| PELI3 \| 1.533 \| DISEASES 114770 \| PGLYRP2 \| 1.668 \| DISEASES 57115 \| PGLYRP4 \| 2.053 \| DISEASES 116154 \| PHACTR3 \| 1.014 \| DISEASES 5284 \| PIGR \| 1.14 \| DISEASES 30814 \| PLA2G2E \| 1.269 \| DISEASES 5535 \| PPP3R2 \| 1.275 \| DISEASES 5542 \| PRB1 \| 1.269 \| DISEASES 639 \| PRDM1 \| 1.007 \| DISEASES 7916 \| PRRC2A \| 1.163 \| DISEASES 8624 \| PSMG1 \| 2.85 \| DISEASES 374308 \| PTCHD3 \| 1.228 \| DISEASES 11251 \| PTGDR2 \| 1.018 \| DISEASES 5742 \| PTGS1 \| 1.106 \| DISEASES 5743 \| PTGS2 \| 3.71 \| DISEASES 26191 \| PTPN22 \| 2.684 \| DISEASES 5788 \| PTPRC \| 1.983 \| DISEASES 5799 \| PTPRN2 \| 1.862 \| DISEASES 5802 \| PTPRS \| 1.378 \| DISEASES 5697 \| PYY \| 2.045 \| DISEASES 55225 \| RAVER2 \| 1.763 \| DISEASES 7905 \| REEP5 \| 1.266 \| DISEASES 5970 \| RELA \| 1.075 \| DISEASES 54546 \| RNF186 \| 3.832 \| DISEASES 54476 \| RNF216 \| 1.637 \| DISEASES 6097 \| RORC \| 2.755 \| DISEASES 864 \| RUNX3 \| 1.943 \| DISEASES 6283 \| S100A12 \| 3.191 \| DISEASES 6280 \| S100A9 \| 2.262 \| DISEASES 170591 \| S100Z \| 1.353 \| DISEASES 6288 \| SAA1 \| 1.421 \| DISEASES 201191 \| SAMD14 \| 1.666 \| DISEASES 22904 \| SBNO2 \| 1.382 \| DISEASES 619383 \| SCARNA9 \| 1.879 \| DISEASES 9919 \| SEC16A \| 1.127 \| DISEASES 6401 \| SELE \| 2.42 \| DISEASES 9037 \| SEMA5A \| 1.114 \| DISEASES 5265 \| SERPINA1 \| 3.165 \| DISEASES 462 \| SERPINC1 \| 2.77 \| DISEASES 59307 \| SIGIRR \| 1.048 \| DISEASES 6564 \| SLC15A1 \| 2.854 \| DISEASES 63027 \| SLC22A23 \| 1.644 \| DISEASES 1811 \| SLC26A3 \| 2.436 \| DISEASES 6520 \| SLC3A2 \| 1.036 \| DISEASES 11254 \| SLC6A14 \| 2.436 \| DISEASES 9353 \| SLIT2 \| 1.075 \| DISEASES 6590 \| SLPI \| 1.664 \| DISEASES 4089 \| SMAD4 \| 1.47 \| DISEASES 27099 \| SND1-IT1 \| 1.719 \| DISEASES 677803 \| SNORA15 \| 2.102 \| DISEASES 26810 \| SNORD41 \| 1.447 \| DISEASES 124460 \| SNX20 \| 2.184 \| DISEASES 8651 \| SOCS1 \| 1.743 \| DISEASES 9021 \| SOCS3 \| 2.44 \| DISEASES 27290 \| SPINK4 \| 2.676 \| DISEASES 6714 \| SRC \| 1.296 \| DISEASES 400410 \| ST20 \| 1.004 \| DISEASES 6772 \| STAT1 \| 2.297 \| DISEASES 6775 \| STAT4 \| 2.99 \| DISEASES 6863 \| TAC1 \| 3.708 \| DISEASES 6865 \| TACR2 \| 2.44 \| DISEASES 256536 \| TCERG1L \| 1.012 \| DISEASES 7010 \| TEK \| 1.201 \| DISEASES 7018 \| TF \| 2.089 \| DISEASES 7033 \| TFF3 \| 2.666 \| DISEASES 24144 \| TFIP11 \| 1.723 \| DISEASES 7037 \| TFRC \| 1.482 \| DISEASES 7052 \| TGM2 \| 1.547 \| DISEASES 7056 \| THBD \| 1.454 \| DISEASES 9414 \| TJP2 \| 1.203 \| DISEASES 7096 \| TLR1 \| 2.125 \| DISEASES 7099 \| TLR4 \| 4.461 \| DISEASES 7100 \| TLR5 \| 3.158 \| DISEASES 10333 \| TLR6 \| 1.071 \| DISEASES 54106 \| TLR9 \| 2.8 \| DISEASES 199953 \| TMEM201 \| 2.388 \| DISEASES 7124 \| TNF \| 6.205 \| DISEASES 7133 \| TNFRSF1B \| 3.177 \| DISEASES 8718 \| TNFRSF25 \| 2.79 \| DISEASES 8771 \| TNFRSF6B \| 1.675 \| DISEASES 8742 \| TNFSF12 \| 1.068 \| DISEASES 9966 \| TNFSF15 \| 4.535 \| DISEASES 1861 \| TOR1A \| 1.456 \| DISEASES 7170 \| TPM3 \| 3.012 \| DISEASES 7189 \| TRAF6 \| 1.733 \| DISEASES 10293 \| TRAIP \| 1.342 \| DISEASES 10107 \| TRIM10 \| 1.277 \| DISEASES 56658 \| TRIM39 \| 1.018 \| DISEASES 54952 \| TRNAU1AP \| 1.194 \| DISEASES 7442 \| TRPV1 \| 1.552 \| DISEASES 85480 \| TSLP \| 1.669 \| DISEASES 7332 \| UBE2L3 \| 1.553 \| DISEASES 9354 \| UBE4A \| 1.879 \| DISEASES 652995 \| UCA1 \| 1.914 \| DISEASES 7421 \| VDR \| 2.256 \| DISEASES 7422 \| VEGFA \| 2.256 \| DISEASES 7432 \| VIP \| 2.682 \| DISEASES 11193 \| WBP4 \| 1.632 \| DISEASES 146198 \| ZFP90 \| 1.017 \| DISEASES 57178 \| ZMIZ1 \| 1.794 \| DISEASES 22891 \| ZNF365 \| 1.847 \| DISEASES 65251 \| ZNF649 \| 2.066 \| DISEASES
Locus	(Waiting for update.)

Disease ID	177
Disease	ulcerative colitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:132) HP:0002583 \| Colitis \| 21 HP:0002664 \| Neoplasia \| 18 HP:0100280 \| Morbus Crohn \| 14 HP:0000999 \| Pyoderma \| 14 HP:0002665 \| Lymphoma \| 9 HP:0003003 \| Colon cancer \| 9 HP:0001903 \| Anemia \| 9 HP:0002633 \| Vasculitis \| 8 HP:0030151 \| Cholangitis \| 7 HP:0004936 \| Blood clot in vein \| 6 HP:0001733 \| Pancreatic inflammation \| 6 HP:0002014 \| Diarrhea \| 6 HP:0002090 \| Pneumonia \| 5 HP:0001890 \| Autoimmune hemolytic anemia \| 5 HP:0030731 \| Carcinoma \| 5 HP:0000979 \| Purpura \| 5 HP:0001878 \| Haemolytic anaemia \| 5 HP:0001907 \| Thromboembolic disease \| 4 HP:0100806 \| Sepsis \| 4 HP:0005305 \| Cerebral vein thrombosis \| 4 HP:0012089 \| Arteritis \| 4 HP:0001369 \| Arthritis \| 4 HP:0002573 \| Bloody diarrhea \| 4 HP:0000716 \| Depression \| 4 HP:0001945 \| Fever \| 4 HP:0012189 \| Hodgkin disease \| 3 HP:0002955 \| Granulomatosis \| 3 HP:0012819 \| Myocarditis \| 3 HP:0001824 \| Weight loss \| 3 HP:0012531 \| Pain \| 3 HP:0005318 \| Cerebral vasculitis \| 3 HP:0004420 \| Arterial thrombosis \| 2 HP:0011950 \| Bronchiolitis \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0002251 \| Hirschsprung megacolon \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0001970 \| Interstitial nephritis \| 2 HP:0011945 \| Cryptogenic organizing pneumonia \| 2 HP:0002097 \| Pulmonary emphysema \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0000554 \| Uveitis \| 2 HP:0000100 \| Nephrosis \| 2 HP:0001735 \| Acute pancreatitis \| 2 HP:0001915 \| Aplastic anemia \| 2 HP:0002098 \| Respiratory distress \| 2 HP:0100749 \| Thoracic pain \| 2 HP:0002639 \| Budd-Chiari syndrome \| 2 HP:0010447 \| Fistula in ano \| 2 HP:0000123 \| Nephritis \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0000112 \| Nephropathy \| 2 HP:0030242 \| Blood clot in portal vein \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0012122 \| Anterior uveitis \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0100507 \| Folate deficiency \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0002908 \| Conjugated hyperbilirubinemia \| 1 HP:0001909 \| Leukemia \| 1 HP:0100534 \| Episcleritis \| 1 HP:0100243 \| Leiomyosarcoma \| 1 HP:0030838 \| Hip pain \| 1 HP:0002094 \| Dyspnea \| 1 HP:0100512 \| Vitamin D deficiency \| 1 HP:0200029 \| Cutaneous vasculitis \| 1 HP:0005263 \| Gastritis \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0012490 \| Inflammation of fat tissue \| 1 HP:0011946 \| Constrictive bronchiolitis \| 1 HP:0000717 \| Autism \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0100726 \| Kaposi's sarcoma \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0002383 \| Encephalitis \| 1 HP:0001123 \| Partial loss of field of vision \| 1 HP:0000739 \| Anxiety \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0012735 \| Coughing \| 1 HP:0005200 \| Retroperitoneal fibrosis \| 1 HP:0001061 \| Acne \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0100896 \| Rectal polyps \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0001048 \| Cavernous angioma \| 1 HP:0010566 \| Hamartoma \| 1 HP:0008282 \| Unconjugated hyperbilirubinemia \| 1 HP:0100281 \| Chronic colitis \| 1 HP:0005506 \| Chronic myeloid leukemia \| 1 HP:0001289 \| Confusion \| 1 HP:0011944 \| Small vessel vasculitis \| 1 HP:0006280 \| Chronic pancreas inflammation \| 1 HP:0012636 \| Retinal vein occlusion \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0200063 \| Colorectal polyposis \| 1 HP:0001081 \| Gallstones \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0002576 \| Intussusception \| 1 HP:0100584 \| Endocarditis \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0004395 \| Malnutrition \| 1 HP:0002028 \| Chronic diarrhea \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0005901 \| Chronic recurrent multifocal osteomyelitis \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0002754 \| Bone infection \| 1 HP:0001873 \| Low platelet count \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0002133 \| Status epilepticus \| 1 HP:0002099 \| Asthma \| 1 HP:0100242 \| Sarcoma \| 1 HP:0000787 \| Renal calculi \| 1 HP:0002326 \| TIA \| 1 HP:0030153 \| Cholangiocarcinoma \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0012424 \| Chorioretinitis \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0012393 \| Allergy \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0006530 \| Interstitial lung disease \| 1 HP:0004789 \| Lactose intolerance \| 1

Disease ID	177
Disease	ulcerative colitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:401) C2711227 \| liver steatosis C2697391 \| rheumatoid arthritis C2697384 \| colon cancer C2697310 \| sarcoidosis C2678504 \| osteoporosis C2632116 \| stenosis C2609250 \| palisaded neutrophilic granulomatous dermatitis C2598155 \| pain C2350476 \| orbital myositis C2240374 \| eosinophilia C2203646 \| jaundice C2186740 \| urticaria C2186532 \| liver disease C2096315 \| headache C2096293 \| vertigo C2048468 \| male infertility C2029884 \| hearing loss C2020637 \| chronic pain C1994997 \| intestinal symptoms C1971021 \| potassium depletion C1963919 \| backwash ileitis C1963747 \| herpes simplex hepatitis C1963274 \| vasculitis C1963266 \| uveitis C1963211 \| pericarditis C1963198 \| pancreatitis C1963178 \| myelitis C1963165 \| malabsorption C1963091 \| diarrhea C1963083 \| cholecystitis C1963064 \| anxiety C1962972 \| proteinuria C1962971 \| myocarditis C1956391 \| temporal arteritis C1839611 \| n syndrome C1834174 \| neutrophil migration C1801950 \| g syndrome C1800706 \| usual interstitial pneumonia C1739152 \| acute alveolitis C1696087 \| uterine fistula C1611280 \| allergy C1608408 \| malignant transformation C1555769 \| pulmonary disease C1550639 \| fistula C1541923 \| infective endocarditis C1527249 \| colorectal cancer C1522057 \| duodenitis C1510475 \| diverticulosis C1510475 \| diverticular disease C1456865 \| ureteral stone C1443924 \| severe diarrhea C1393529 \| vascular complications C1384353 \| infestation C1373218 \| immunosuppression C1368829 \| hyperalimentation C1336864 \| undifferentiated carcinoma of the rectum C1335690 \| squamous cell carcinoma of the rectum C1335690 \| rectal squamous cell carcinoma C1335685 \| rectal lymphoma C1335681 \| rectal kaposi's sarcoma C1335513 \| mucinous adenocarcinoma of the prostate C1333112 \| colorectal dysplasia C1333100 \| colonic squamous cell carcinoma C1333091 \| colonic kaposi's sarcoma C1321033 \| toxic megacolon due to clostridium difficile C1302363 \| colonic dysplasia C1275718 \| granulomatous rosacea C1270880 \| pressure urticaria C1268935 \| microangiopathic hemolytic anemia C1257843 \| pseudomembranous colitis C1167732 \| pleuropericarditis C1167650 \| chronic polyneuropathy C1142420 \| hepatitis b reactivation C1142272 \| neutrophilic dermatosis C1136085 \| monoclonal gammapathy C1112565 \| pneumatosis intestinalis C1096000 \| bronchopulmonary disease C1090821 \| sepsis C1000483 \| anemia C0949691 \| spondyloarthropathy C0949690 \| spondyloarthritis C0949022 \| rectal cancer C0947622 \| gallstones C0940937 \| precancerous lesions C0878643 \| epiphenomenon C0878500 \| intraepithelial neoplasia C0878500 \| epithelial dysplasia C0868908 \| pancolitis C0860204 \| cholestatic liver disease C0857496 \| thromboembolic event C0856761 \| budd-chiari syndrome C0856169 \| endothelial dysfunction C0854532 \| myopericarditis C0853030 \| macroamylasemia C0852879 \| pulmonary alveolar hemorrhage C0850639 \| premalignant lesion C0836924 \| thrombocytosis C0748159 \| pulmonary involvement C0747733 \| polychondritis C0740985 \| acute anemia C0740277 \| carcinoma of bile duct C0740277 \| bile duct carcinoma C0728936 \| circulatory disorders C0702094 \| agranulocytosis C0700361 \| distress C0699949 \| airways disease C0699790 \| colonic carcinoma C0699790 \| colon carcinoma C0699790 \| carcinoma of the colon C0677607 \| hashimoto's disease C0598608 \| hyperhomocysteinemia C0586370 \| dysplasia of the rectum C0586367 \| low-grade colorectal dysplasia C0581883 \| deafness C0566602 \| primary sclerosing cholangitis C0549493 \| alveolitis C0549297 \| swelling of the ear C0547058 \| pseudopolyposis C0524910 \| chronic hepatitis c C0521607 \| peritoneal fibrosis C0520463 \| chronic active hepatitis C0519037 \| colonic lymphoma C0517555 \| venous thrombosis C0451641 \| urolithiasis C0426576 \| gastrointestinal symptoms C0410422 \| chronic recurrent multifocal osteomyelitis C0406650 \| linear iga disease C0406650 \| linear iga dermatosis C0406650 \| linear iga bullous dermatosis C0406304 \| digitate dermatosis C0398650 \| immune thrombocytopenic purpura C0398625 \| protein c deficiency C0398623 \| thrombophilia C0398623 \| hypercoagulable state C0398623 \| hypercoagulability C0376620 \| pouchitis C0348754 \| hepatotoxicity C0345904 \| liver cancer C0345050 \| annuloaortic ectasia C0343190 \| cutaneous polyarteritis nodosa C0343101 \| wells' syndrome C0343101 \| eosinophilic cellulitis C0342801 \| thiopurine s-methyltransferase deficiency C0341402 \| rectal perforation C0341335 \| cytomegalovirus colitis C0341178 \| multiple gastric ulcers C0340987 \| splenic atrophy C0340704 \| superior mesenteric vein thrombosis C0340359 \| prosthetic valve endocarditis C0340221 \| tracheal obstruction C0338573 \| cerebral venous sinus thrombosis C0334108 \| polyposis C0281779 \| anal condyloma acuminatum C0275685 \| listeria septicemia C0272416 \| splenic vein thrombosis C0272412 \| splenic abscess C0272404 \| hyposplenism C0272286 \| immune thrombocytopenia C0272126 \| evans' syndrome C0271683 \| motor polyneuropathy C0271270 \| cogan's syndrome C0268382 \| renal amyloidosis C0267963 \| pancreatic insufficiency C0267792 \| hepatobiliary disease C0267557 \| secretory diarrhea C0267508 \| colitis cystica profunda C0267466 \| colonic stricture C0267466 \| colon stenosis C0267373 \| intestinal bleeding C0267179 \| gastrocolic fistula C0267166 \| gastroduodenitis C0267000 \| pyostomatitis vegetans C0265070 \| mondor's disease C0265008 \| aortocaval fistula C0263505 \| alopecia universalis C0262471 \| ent problem C0259749 \| autonomic neuropathy C0242770 \| bronchiolitis obliterans organizing pneumonia C0242770 \| bronchiolitis obliterans organising pneumonia C0241910 \| autoimmune chronic active hepatitis C0241266 \| subcutaneous abscess C0238463 \| papillary thyroid carcinoma C0238304 \| chronic interstitial nephritis C0238051 \| cerebral vasculitis C0238003 \| appendix adenocarcinoma C0235782 \| carcinoma of the gallbladder C0235782 \| carcinoma of the gall bladder C0234131 \| motor dysfunction C0232495 \| lower abdominal pain C0221773 \| hyperamylasemia C0221406 \| cushing's disease C0221014 \| secondary amyloidosis C0221002 \| primary hyperparathyroidism C0206695 \| neuroendocrine carcinoma C0206186 \| oral hairy leukoplakia C0206062 \| interstitial lung disease C0206061 \| interstitial pneumonitis C0198632 \| pneumoperitoneum C0178416 \| hypoplastic anemia C0162291 \| retinal ischemia C0155773 \| portal vein thrombosis C0155354 \| scleromalacia perforans C0155223 \| lacrimal gland inflammation C0154841 \| central retinal vein thrombosis C0152966 \| pneumococcal septicaemia C0152486 \| salmonella sepsis C0152250 \| thrombophlebitis migrans C0151945 \| cerebral venous thrombosis C0151942 \| arterial thrombosis C0151731 \| hepatic infarction C0151693 \| adrenal haemorrhage C0151436 \| leukocytoclastic vasculitis C0149871 \| deep venous thrombosis C0149678 \| epstein-barr virus infection C0149521 \| chronic pancreatitis C0149514 \| bronchitis C0087086 \| thrombi C0086132 \| depressive symptoms C0085655 \| polymyositis C0085652 \| pyoderma gangrenosum C0085641 \| pustular rash C0085605 \| hepatic failure C0085273 \| parvovirus b19 infection C0085077 \| sweet's syndrome C0085077 \| sweet syndrome C0079293 \| epidermolysis bullosa acquisita C0043092 \| wegener's granulomatosis C0042373 \| vascular disease C0042165 \| anterior uveitis C0042024 \| incontinence C0041296 \| tuberculosis C0040156 \| thyrotoxicosis C0040053 \| thrombosis C0040038 \| thromboembolism C0040038 \| thromboembolic disease C0040034 \| thrombocytopenia C0039841 \| thiamine deficiency C0039263 \| takayasu's disease C0039263 \| takayasu's arteritis C0039263 \| takayasu arteritis C0038463 \| strongyloidiasis C0038454 \| cerebral infarction C0038013 \| ankylosing spondylitis C0037974 \| spirochaetosis C0037763 \| spasm C0037285 \| skin manifestation C0037284 \| skin lesions C0037198 \| sinus thrombosis C0037074 \| sigmoiditis C0036690 \| septicemia C0036690 \| septicaemia C0036220 \| kaposi's sarcoma C0035204 \| respiratory disorders C0035204 \| respiratory diseases C0034895 \| rectovaginal fistulas C0034150 \| purpura C0034067 \| emphysema C0034065 \| pulmonary embolism C0033860 \| psoriasis C0033845 \| benign intracranial hypertension C0033838 \| kimura's disease C0033252 \| rectosigmoiditis C0033246 \| rectal inflammation C0032827 \| potassium deficiency C0032568 \| pseudopolyp C0032453 \| relapsing polychondritis C0032305 \| pneumocystis carinii pneumonia C0032249 \| sideropenic dysphagia C0032231 \| pleuritis C0031129 \| periphlebitis C0031111 \| periostitis C0031052 \| pericholangitis C0031036 \| polyarteritis nodosa C0030920 \| peptic ulcer C0030297 \| pancreatic neoplasm C0030297 \| neoplasm of the pancreas C0030286 \| pancreatic disease C0029440 \| osteomas C0029166 \| oral manifestation C0029132 \| optic neuropathy C0027765 \| neurologic disorders C0027726 \| nephrotic syndrome C0027547 \| necrotizing scleritis C0027121 \| myositis C0026896 \| myasthenia gravis C0026691 \| kawasaki disease C0026684 \| appendiceal mucocele C0026266 \| mitral insufficiency C0025517 \| metabolic disorders C0025162 \| toxic megacolon C0025160 \| megacolon C0024473 \| magnesium deficiency C0024299 \| malignant lymphoma C0024299 \| lymphoma C0024291 \| hemophagocytic syndrome C0024143 \| lupus nephritis C0024141 \| lupus syndrome C0024115 \| lung disease C0024081 \| ludwig's angina C0023903 \| hepatoma C0023895 \| liver diseases C0023895 \| hepatopathy C0023646 \| lichen planus C0023487 \| acute promyelocytic leukemia C0023467 \| acute myelogenous leukemia C0023240 \| legionella infection C0023223 \| leg ulcers C0022951 \| lactose malabsorption C0022951 \| lactose intolerance C0022658 \| nephropathy C0022408 \| arthropathy C0022408 \| arthropathies C0022354 \| obstructive jaundice C0022116 \| ischemia C0022104 \| irritable bowel syndrome C0021933 \| intussusception C0021831 \| bowel disease C0021390 \| inflammatory bowel disease C0020877 \| ileitis C0020550 \| hyperthyroidism C0020437 \| hypercalcemia C0019693 \| hiv infection C0019621 \| langerhan's cell histiocytosis C0019112 \| haemorrhoids C0019080 \| hemorrhage C0018920 \| cavernous hemangioma C0018784 \| sensorineural hearing loss C0018784 \| sensorineural deafness C0018378 \| guillain-barre syndrome C0018099 \| gout C0017665 \| membranous glomerulonephritis C0017662 \| mesangiocapillary glomerulonephritis C0017661 \| iga nephropathy C0017658 \| glomerulonephritis C0017531 \| angiofollicular lymph node hyperplasia C0017155 \| menetrier's disease C0017155 \| menetrier disease C0016470 \| food hypersensitivity C0016436 \| folliculitis C0016412 \| folate deficiency C0015230 \| skin rash C0014743 \| erythema nodosum C0014130 \| endocrine disease C0014118 \| endocarditis C0012819 \| colonic diverticulosis C0012739 \| disseminated intravascular coagulation C0012624 \| spondylodiscitis C0011991 \| diarrhoea C0011608 \| dermatitis herpetiformis C0010823 \| cytomegalovirus infection C0010481 \| cushing syndrome C0010414 \| cryptococcus neoformans infection C0010346 \| crohn's disease C0009404 \| colorectal neoplasm C0009402 \| colorectal carcinomas C0009402 \| colorectal carcinoma C0009402 \| carcinoma of the large intestine C0009375 \| colonic neoplasms C0009373 \| colonic disease C0008680 \| chronic eosinophilic pneumonia C0008497 \| choriocarcinoma C0008370 \| cholestasis C0008313 \| sclerosing cholangitis C0008312 \| primary biliary cirrhosis C0008311 \| cholangitis C0008033 \| pleuritic pain C0007773 \| cerebral arteritis C0007177 \| pericardial tamponade C0007177 \| cardiac tamponade C0007113 \| rectal carcinoma C0007113 \| carcinoma of the rectum C0007102 \| colonic cancer C0007102 \| colon cancers C0007102 \| cancer of the colon C0007095 \| carcinoid tumours C0006272 \| bronchiolitis obliterans C0006271 \| bronchiolitis C0006267 \| bronchiectasis C0006261 \| bronchial disease C0005395 \| bile duct disorders C0004936 \| mental disorders C0004610 \| bacteremia C0004610 \| bacteraemia C0004096 \| bronchial asthma C0003864 \| arthritis C0003862 \| arthralgia C0003510 \| aortitis syndrome C0003509 \| aortitis C0003504 \| aortic incompetence C0002880 \| autoimmune hemolytic anemia C0002880 \| autoimmune haemolytic anaemia C0002878 \| hemolytic anemia C0002878 \| haemolytic anaemia C0002871 \| anaemia C0002438 \| amebiasis C0001883 \| airway obstruction C0001815 \| idiopathic myelofibrosis C0001430 \| adenoma C0001418 \| adenocarcinoma C0001339 \| acute pancreatitis C0000737 \| abdominal pain
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:134) C0007113 \| rectal cancer \| 38 C0009402 \| colorectal cancer \| 37 C0021831 \| bowel disease \| 25 C0021390 \| inflammatory bowel disease \| 21 C0376620 \| pouchitis \| 15 C0010346 \| crohn's disease \| 14 C0040053 \| thrombosis \| 13 C0085652 \| pyoderma gangrenosum \| 12 C0010823 \| cytomegalovirus infection \| 11 C0566602 \| primary sclerosing cholangitis \| 11 C0008313 \| sclerosing cholangitis \| 11 C0024299 \| lymphoma \| 9 C0007102 \| colon cancer \| 9 C0042384 \| vasculitis \| 8 C0008311 \| cholangitis \| 7 C0002871 \| anemia \| 7 C0011991 \| diarrhea \| 6 C0042487 \| venous thrombosis \| 6 C0868908 \| pancolitis \| 6 C0030305 \| pancreatitis \| 6 C0034150 \| purpura \| 5 C0036690 \| sepsis \| 4 C0151945 \| cerebral venous thrombosis \| 4 C0334108 \| polyposis \| 4 C0020877 \| ileitis \| 4 C0003864 \| arthritis \| 4 C0040038 \| thromboembolism \| 4 C0027059 \| myocarditis \| 3 C0002878 \| haemolytic anaemia \| 3 C0238051 \| cerebral vasculitis \| 3 C1302363 \| colorectal dysplasia \| 3 C0043117 \| immune thrombocytopenic purpura \| 3 C1963919 \| backwash ileitis \| 3 C0002880 \| autoimmune haemolytic anaemia \| 3 C0039263 \| takayasu arteritis \| 3 C0037198 \| sinus thrombosis \| 3 C0011991 \| diarrhoea \| 3 C0030193 \| pain \| 3 C0041296 \| tuberculosis \| 3 C0085077 \| sweet's syndrome \| 3 C0854532 \| myopericarditis \| 2 C0025160 \| megacolon \| 2 C0024115 \| lung disease \| 2 C0002880 \| autoimmune hemolytic anemia \| 2 C0022658 \| nephropathy \| 2 C0006271 \| bronchiolitis \| 2 C0013990 \| emphysema \| 2 C0027726 \| nephrotic syndrome \| 2 C0026684 \| appendiceal mucocele \| 2 C0242770 \| bronchiolitis obliterans organizing pneumonia \| 2 C0042373 \| vascular disease \| 2 C0002871 \| anaemia \| 2 C0042164 \| uveitis \| 2 C0151436 \| leukocytoclastic vasculitis \| 2 C0878500 \| intraepithelial neoplasia \| 2 C0406650 \| linear iga dermatosis \| 2 C0004610 \| bacteremia \| 2 C0013298 \| duodenitis \| 2 C0856761 \| budd-chiari syndrome \| 2 C0001418 \| adenocarcinoma \| 2 C0007113 \| rectal carcinoma \| 2 C0001339 \| acute pancreatitis \| 2 C0231303 \| distress \| 2 C0267166 \| gastroduodenitis \| 2 C0003873 \| rheumatoid arthritis \| 2 C0024291 \| hemophagocytic syndrome \| 2 C0002878 \| hemolytic anemia \| 2 C0151942 \| arterial thrombosis \| 2 C0155223 \| lacrimal gland inflammation \| 1 C0027121 \| myositis \| 1 C0029166 \| oral manifestation \| 1 C0040034 \| thrombocytopenia \| 1 C0267373 \| intestinal bleeding \| 1 C0000737 \| abdominal pain \| 1 C0032568 \| pseudopolyposis \| 1 C0017155 \| menetrier disease \| 1 C0009402 \| colorectal carcinoma \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0022951 \| lactose intolerance \| 1 C0017661 \| iga nephropathy \| 1 C0023895 \| liver disease \| 1 C1608408 \| malignant transformation \| 1 C0039263 \| takayasu's disease \| 1 C0018784 \| sensorineural hearing loss \| 1 C1384666 \| hearing loss \| 1 C0426576 \| gastrointestinal symptoms \| 1 C0009402 \| colorectal carcinomas \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0087086 \| thrombi \| 1 C0001430 \| adenoma \| 1 C0008350 \| gallstones \| 1 C0149521 \| chronic pancreatitis \| 1 C0949691 \| spondyloarthropathy \| 1 C0949690 \| spondyloarthritis \| 1 C0017658 \| glomerulonephritis \| 1 C1994997 \| intestinal symptoms \| 1 C0037285 \| skin manifestation \| 1 C0338573 \| cerebral venous sinus thrombosis \| 1 C0747733 \| polychondritis \| 1 C0262471 \| ent problem \| 1 C0036220 \| kaposi's sarcoma \| 1 C1335690 \| rectal squamous cell carcinoma \| 1 C0155773 \| portal vein thrombosis \| 1 C0009814 \| stenosis \| 1 C0272412 \| splenic abscess \| 1 C0007177 \| cardiac tamponade \| 1 C0002438 \| amebiasis \| 1 C0037280 \| infestation \| 1 C0341335 \| cytomegalovirus colitis \| 1 C0016412 \| folate deficiency \| 1 C0007177 \| pericardial tamponade \| 1 C0007785 \| cerebral infarction \| 1 C0021933 \| intussusception \| 1 C1510475 \| diverticulosis \| 1 C0586367 \| low-grade colorectal dysplasia \| 1 C0036202 \| sarcoidosis \| 1 C0002111 \| allergy \| 1 C0032320 \| pneumoperitoneum \| 1 C0016169 \| fistula \| 1 C0042165 \| anterior uveitis \| 1 C0410422 \| chronic recurrent multifocal osteomyelitis \| 1 C0032453 \| relapsing polychondritis \| 1 C0014118 \| endocarditis \| 1 C2350476 \| orbital myositis \| 1 C0014121 \| infective endocarditis \| 1 C0521607 \| peritoneal fibrosis \| 1 C0009404 \| colorectal neoplasm \| 1 C0006272 \| bronchiolitis obliterans \| 1 C0003467 \| anxiety \| 1 C0019080 \| hemorrhage \| 1 C0206062 \| interstitial lung disease \| 1 C0086132 \| depressive symptoms \| 1 C0406650 \| linear iga disease \| 1 C0728936 \| circulatory disorders \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:2)
Variant ID	CHR	POS	Gene	Samples	AF	Beta/OR (SE)/(CI)	Type	Population	Reference
rs7809799	7	98760504	SMURF1, KPNA7	2746	0.04	1.56	GWAS	European	http://www.ncbi.nlm.nih.gov/pubmed/20228798
rs12422544	12	40528432	NR	27432	0.01915	1.2153448	GWAS	European	http://www.ncbi.nlm.nih.gov/pubmed/26192919

All Snps(Total Genotypes:922)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1000113	19098858	8792	TNFRSF11A	umls:C0009324	BeFree	Allele and genotype frequencies of rs1000113 and rs4958847 were determined in 823 CD (265 younger than 19 years at diagnosis), 353 ulcerative colitis (UC) (130 younger than 19 years at diagnosis), and 578 controls.	0.000271442	2009	IRGM	5	150860514	C	T
rs1004819	17786191	149233	IL23R	umls:C0009324	BeFree	rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.	0.326936272	2007	IL23R	1	67204530	G	A
rs1004819	22735800	149233	IL23R	umls:C0009324	BeFree	IL-23 receptor gene rs7517847 and rs1004819 SNPs in ulcerative colitis.	0.326936272	2014	IL23R	1	67204530	G	A
rs10063949	24284447	27034	ACAD8	umls:C0009324	BeFree	Genomic DNA samples from patients with CD (n = 162) and UC (n = 149) from the Manitoba IBD Cohort Study and ethnically matched controls (n = 142) were genotyped for 3 SLC23A1 polymorphisms (rs6596473, rs33972313, and rs10063949) by using TaqMan assays.	0.010043349	2014	SLC23A1	5	139383837	T	C
rs10063949	24284447	9963	SLC23A1	umls:C0009324	BeFree	A strong linkage disequilibrium (LD) was observed across the SLC23A1 region (variation rs6596473 with rs10063949) for CD and UC (D' = 0.94 and 0.96, respectively).	0.000271442	2014	SLC23A1	5	139383837	T	C
rs1016883	23128233	5334	PLCL1	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	PLCL1	2	198016944	G	A
rs10174238	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191108308	G	A
rs10181656	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191105153	G	C
rs1042522	20309662	7157	TP53	umls:C0009324	BeFree	R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history.	0.026664774	2010	TP53	17	7676154	G	T,C
rs1045642	17260353	5243	ABCB1	umls:C0009324	BeFree	A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212 control subjects were investigated for the presence of MDR1 G2677T/A and C3435T polymorphisms.	0.054051573	2007	ABCB1	7	87509329	A	T,G
rs1045642	16462040	5243	ABCB1	umls:C0009324	BeFree	MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.	0.054051573	2006	ABCB1	7	87509329	A	T,G
rs1045642	24687344	5243	ABCB1	umls:C0009324	BeFree	In regard to the clinical implications of MDR1 SNPs, it was found in large meta-analysis that C3435T SNP was associated with a slight increase in the susceptibility to ulcerative colitis and cancer and was related with slight modifications in tacrolimus pharmacokinetics and platinum-based chemotherapy response in lung cancer.	0.054051573	2013	ABCB1	7	87509329	A	T,G
rs1045642	17242936	5243	ABCB1	umls:C0009324	BeFree	The frequency of C3435T MDR1 gene polymorphism in Iranian patients with ulcerative colitis.	0.054051573	2007	ABCB1	7	87509329	A	T,G
rs1045642	12512026	5243	ABCB1	umls:C0009324	BeFree	Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.	0.054051573	2003	ABCB1	7	87509329	A	T,G
rs1045642	15685540	5243	ABCB1	umls:C0009324	BeFree	This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).	0.054051573	2005	ABCB1	7	87509329	A	T,G
rs10491434	24911414	60498	IGAN1	umls:C0009324	BeFree	These four variants are implicated in complex phenotypes such as ulcerative colitis and AIDS progression disease (rs10491434), Celiac disease (rs2762051), Crohn's disease, IgA nephropathy and early-onset inflammatory bowel disease (rs713875) and height (rs6569648).	0.000271442	2014	IL7R	5	35877812	A	G
rs1049353	20195480	1268	CNR1	umls:C0009324	BeFree	The CNR1 p.Thr453Thr polymorphism appears to modulate UC susceptibility and the CD phenotype.	0.002638474	2010	CNR1	6	88143916	C	T
rs10499563	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	NA	7	22720869	T	C
rs10499563	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	NA	7	22720869	T	C
rs10499563	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	NA	7	22720869	T	C
rs10499563	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	NA	7	22720869	T	C
rs10499563	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	NA	7	22720869	T	C
rs10499563	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	NA	7	22720869	T	C
rs10499563	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	NA	7	22720869	T	C
rs10499563	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	NA	7	22720869	T	C
rs10499563	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	NA	7	22720869	T	C
rs10499563	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	NA	7	22720869	T	C
rs10499563	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	NA	7	22720869	T	C
rs10499563	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	NA	7	22720869	T	C
rs10499563	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	NA	7	22720869	T	C
rs10499563	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	NA	7	22720869	T	C
rs10499563	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	NA	7	22720869	T	C
rs10758669	24385239	3717	JAK2	umls:C0009324	BeFree	JAK2 rs10758669 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.	0.131368221	2015	NA	9	4981602	C	A
rs10758669	22065112	6774	STAT3	umls:C0009324	BeFree	Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.	0.135254284	2012	NA	9	4981602	C	A
rs10758669	20228799	10171	RCL1	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.004734064	2010	NA	9	4981602	C	A
rs10758669	22269120	9034	CCRL2	umls:C0009324	BeFree	Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.	0.001085767	2012	NA	9	4981602	C	A
rs10758669	21297633	10171	RCL1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.004734064	2011	NA	9	4981602	C	A
rs10758669	22065112	3717	JAK2	umls:C0009324	BeFree	Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.	0.131368221	2012	NA	9	4981602	C	A
rs10758669	20228799	3717	JAK2	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.131368221	2010	NA	9	4981602	C	A
rs10781499	21297633	64170	CARD9	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.250282454	2011	CARD9	9	136371953	G	A
rs10781499	21297633	64170	CARD9	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.250282454	2011	CARD9	9	136371953	G	A
rs10781500	19915572	64170	CARD9	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.250282454	2009	CARD9	9	136374886	C	T
rs10800309	20228799	9103	FCGR2C	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002367032	2010	NA	1	161502368	A	G
rs10800309	20228799	2212	FCGR2A	umls:C0009324	GAD	[After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3).]	0.248186863	2010	NA	1	161502368	A	G
rs10800309	20228799	257177	CFAP126	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002367032	2010	NA	1	161502368	A	G
rs10883365	21049557	159296	NKX2-3	umls:C0009324	BeFree	NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).	0.257816813	2010	LINC01475	10	99528007	G	A
rs10889677	19122664	149233	IL23R	umls:C0009324	GWASCAT	Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.	0.326936272	2009	IL23R	1	67259437	C	A
rs10975003	19915573	3717	JAK2	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.131368221	2009	NA	9	5213687	T	C
rs10975003	19915573	11172	INSL6	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.002367032	2009	NA	9	5213687	T	C
rs10975003	19915573	3641	INSL4	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.002367032	2009	NA	9	5213687	T	C
rs11150589	23128233	3683	ITGAL	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12272435	2012	ITGAL	16	30471173	T	C
rs11190140	20228799	159296	NKX2-3	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.257816813	2010	NKX2-3;LINC01475	10	99531836	T	C
rs11190140	20228799	159296	NKX2-3	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.257816813	2010	NKX2-3;LINC01475	10	99531836	T	C
rs11190140	20228799	101927324	LINC01475	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.12	2010	NKX2-3;LINC01475	10	99531836	T	C
rs11205387	19068216	1893	ECM1	umls:C0009324	BeFree	We also genotyped the UC-associated ECM1 variant rs11205387 in 1560 CD patients and 3028 controls.	0.126991475	2009	ECM1;LOC105371435	1	150510262	G	A
rs11209026	24611330	149233	IL23R	umls:C0009324	BeFree	The aim of this study was to determine whether the specific rs11209026 and rs7530511 single-nucleotide polymorphisms in the Interleukin-23 receptor gene are associated with Crohn's disease and ulcerative colitis in a Croatian patient population.	0.326936272	2014	IL23R	1	67240275	G	A
rs11209026	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	IL23R	1	67240275	G	A
rs11209026	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	IL23R	1	67240275	G	A
rs11209026	20082483	64127	NOD2	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.233979892	2010	IL23R	1	67240275	G	A
rs11209026	20192940	149233	IL23R	umls:C0009324	GAD	[IL23R was expressed in both CD and UC with a great variability.]	0.326936272	2010	IL23R	1	67240275	G	A
rs11209026	19276991	149233	IL23R	umls:C0009324	BeFree	We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.	0.326936272	2009	IL23R	1	67240275	G	A
rs11209026	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	IL23R	1	67240275	G	A
rs11209026	21297633	149233	IL23R	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.326936272	2011	IL23R	1	67240275	G	A
rs11209026	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	IL23R	1	67240275	G	A
rs11209026	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	IL23R	1	67240275	G	A
rs11209026	17877509	149233	IL23R	umls:C0009324	BeFree	Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis.	0.326936272	2007	IL23R	1	67240275	G	A
rs11209026	17894849	149233	IL23R	umls:C0009324	BeFree	We also provide further evidence for association of rs11209026 with UC and a report of an additive effect between IL23R and CARD15 genotypes in CD.	0.326936272	2007	IL23R	1	67240275	G	A
rs11209026	19915572	149233	IL23R	umls:C0009324	GWASCAT	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	0.326936272	2009	IL23R	1	67240275	G	A
rs11209026	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	IL23R	1	67240275	G	A
rs11209026	19122664	149233	IL23R	umls:C0009324	GWASCAT	Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.	0.326936272	2009	IL23R	1	67240275	G	A
rs11209026	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	IL23R	1	67240275	G	A
rs11209026	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	IL23R	1	67240275	G	A
rs11209026	19276991	55054	ATG16L1	umls:C0009324	BeFree	We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.	0.03283333	2009	IL23R	1	67240275	G	A
rs11209026	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	IL23R	1	67240275	G	A
rs11209026	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	IL23R	1	67240275	G	A
rs11209026	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	IL23R	1	67240275	G	A
rs11209026	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	IL23R	1	67240275	G	A
rs11209026	20082483	55054	ATG16L1	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.03283333	2010	IL23R	1	67240275	G	A
rs11209026	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	IL23R	1	67240275	G	A
rs11209026	19294505	149233	IL23R	umls:C0009324	BeFree	The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.	0.326936272	2010	IL23R	1	67240275	G	A
rs11209026	20082483	149233	IL23R	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.326936272	2010	IL23R	1	67240275	G	A
rs11209026	17786191	149233	IL23R	umls:C0009324	BeFree	rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.	0.326936272	2007	IL23R	1	67240275	G	A
rs11264799	17389014	64127	NOD2	umls:C0009324	BeFree	Our aim was to study the role of two promoter SNPs of the FCRL3 gene (-169A>G, rs7528684 and -110C>T, rs11264799) in patients with IBD and their interaction with HLA-DRB1 and CARD15 in patients with UC and CD, respectively.	0.233979892	2007	FCRL3	1	157700967	C	T
rs1126510	23128233	5739	PTGIR	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	PTGIR	19	46620526	A	G
rs1127233	17058067	4583	MUC2	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.081628651	2006	MUC13	3	124908177	T	G
rs1127233	17058067	4585	MUC4	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.000542884	2006	MUC13	3	124908177	T	G
rs1127233	17058067	56667	MUC13	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.000271442	2006	MUC13	3	124908177	T	G
rs11465996	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	LY96	8	73989727	C	G
rs11465996	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	LY96	8	73989727	C	G
rs11465996	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	LY96	8	73989727	C	G
rs11465996	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	LY96	8	73989727	C	G
rs11465996	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	LY96	8	73989727	C	G
rs11465996	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	LY96	8	73989727	C	G
rs11465996	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	LY96	8	73989727	C	G
rs11465996	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	LY96	8	73989727	C	G
rs11465996	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	LY96	8	73989727	C	G
rs11465996	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	LY96	8	73989727	C	G
rs11465996	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	LY96	8	73989727	C	G
rs11465996	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	LY96	8	73989727	C	G
rs11465996	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	LY96	8	73989727	C	G
rs11465996	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	LY96	8	73989727	C	G
rs11465996	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	LY96	8	73989727	C	G
rs11465996	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	LY96	8	73989727	C	G
rs11465996	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	LY96	8	73989727	C	G
rs11465996	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	LY96	8	73989727	C	G
rs11465996	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	LY96	8	73989727	C	G
rs11465996	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	LY96	8	73989727	C	G
rs11465996	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	LY96	8	73989727	C	G
rs11465996	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	LY96	8	73989727	C	G
rs11465996	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	LY96	8	73989727	C	G
rs11465996	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	LY96	8	73989727	C	G
rs11465996	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	LY96	8	73989727	C	G
rs11465996	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	LY96	8	73989727	C	G
rs11465996	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	LY96	8	73989727	C	G
rs11465996	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	LY96	8	73989727	C	G
rs11540654	20309662	7157	TP53	umls:C0009324	BeFree	R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history.	0.026664774	2010	TP53	17	7676040	C	T,G,A
rs11554257	20848476	9966	TNFSF15	umls:C0009324	BeFree	Comparison of the MR-UC subjects with healthy controls confirmed the contribution of the major histocompatibility complex to severe UC (peak association: rs17207986, P = 1.4 × 10(-16)) and provided genome-wide suggestive association at the TNFSF15 (TL1A) locus (peak association: rs11554257, P = 1.4 × 10(-6)).	0.259445464	2010	NA	9	114842790	T	C
rs11568563	22685416	6579	SLCO1A2	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	SLCO1A2	12	21304500	T	G
rs11568563	22685416	3663	IRF5	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.121357209	2012	SLCO1A2	12	21304500	T	G
rs11568563	22685416	22915	MMRN1	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	SLCO1A2	12	21304500	T	G
rs11584383	20228799	647215	MROH3P	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.122367032	2010	MROH3P	1	200966738	T	C
rs11584383	20228799	647215	MROH3P	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.122367032	2010	MROH3P	1	200966738	T	C
rs11614913	20848167	574501	MIR499A	umls:C0009324	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.	0.000271442	2011	MIR196A2	12	53991815	C	T
rs11614913	20848167	406938	MIR146A	umls:C0009324	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.	0.000542884	2011	MIR196A2	12	53991815	C	T
rs11676348	21297633	3579	CXCR2	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.122638474	2011	NA	2	218145423	C	T
rs11739663	21297633	6550	SLC9A3	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.005276948	2011	NA	5	593968	T	C
rs11805303	22426692	64127	NOD2	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.233979892	2012	IL23R	1	67209833	C	T
rs11805303	22426692	149233	IL23R	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.326936272	2012	IL23R	1	67209833	C	T
rs11805303	22426692	5771	PTPN2	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.129358507	2012	IL23R	1	67209833	C	T
rs11825977	17058067	4585	MUC4	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.000542884	2006	NA	11	1075920	G	A
rs11825977	17058067	56667	MUC13	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.000271442	2006	NA	11	1075920	G	A
rs11825977	17058067	4583	MUC2	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.081628651	2006	NA	11	1075920	G	A
rs11889341	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191079016	C	T
rs11938228	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR2	4	153700794	C	A
rs11938228	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR2	4	153700794	C	A
rs11938228	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR2	4	153700794	C	A
rs11938228	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR2	4	153700794	C	A
rs11938228	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR2	4	153700794	C	A
rs11938228	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR2	4	153700794	C	A
rs11938228	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR2	4	153700794	C	A
rs11938228	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR2	4	153700794	C	A
rs11938228	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR2	4	153700794	C	A
rs11938228	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR2	4	153700794	C	A
rs11938228	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR2	4	153700794	C	A
rs11938228	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR2	4	153700794	C	A
rs11938228	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR2	4	153700794	C	A
rs11938228	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR2	4	153700794	C	A
rs11938228	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR2	4	153700794	C	A
rs12261843	21297633	219771	CCNY	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.252735362	2011	CCNY	10	35265126	T	G
rs12261843	21297633	219771	CCNY	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.252735362	2011	CCNY	10	35265126	T	G
rs12377632	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	TLR4	9	117710452	T	C
rs12377632	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	TLR4	9	117710452	T	C
rs12377632	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	TLR4	9	117710452	T	C
rs12377632	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	TLR4	9	117710452	T	C
rs12377632	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	TLR4	9	117710452	T	C
rs12377632	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	TLR4	9	117710452	T	C
rs12377632	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	TLR4	9	117710452	T	C
rs12377632	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	TLR4	9	117710452	T	C
rs12377632	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	TLR4	9	117710452	T	C
rs12377632	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	TLR4	9	117710452	T	C
rs12377632	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	TLR4	9	117710452	T	C
rs12377632	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	TLR4	9	117710452	T	C
rs12377632	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	TLR4	9	117710452	T	C
rs12612347	19944697	151306	GPBAR1	umls:C0009324	BeFree	Of 15 established ulcerative colitis susceptibility loci, significant replication was obtained at chromosomes 2q35 and 3p21 (rs12612347: OR, 1.26; 95% CI, 1.06-1.50; and rs3197999: OR, 1.22; 95% CI, 1.02-1.47, respectively), with circumstantial evidence supporting the G-protein-coupled bile acid receptor 1 and macrophage-stimulating 1, respectively, as the likely disease genes.	0.002909916	2010	NA	2	218192615	A	G
rs1297265	23511034	7332	UBE2L3	umls:C0009324	BeFree	FOS, UBE2L3, the JAK2 gene region, and rs1297265 at chromosome arm 21q21.1 likely play a role in both Crohn's disease and UC.	0.000542884	2013	LOC101927745	21	15444732	A	G
rs1297265	21297633	8204	NRIP1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.004734064	2011	LOC101927745	21	15444732	A	G
rs1297265	23511034	3717	JAK2	umls:C0009324	BeFree	FOS, UBE2L3, the JAK2 gene region, and rs1297265 at chromosome arm 21q21.1 likely play a role in both Crohn's disease and UC.	0.131368221	2013	LOC101927745	21	15444732	A	G
rs1297265	23511034	2353	FOS	umls:C0009324	BeFree	FOS, UBE2L3, the JAK2 gene region, and rs1297265 at chromosome arm 21q21.1 likely play a role in both Crohn's disease and UC.	0.000542884	2013	LOC101927745	21	15444732	A	G
rs13003464	20228799	5966	REL	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002909916	2010	PUS10	2	60959694	A	G
rs13003464	20228799	150962	PUS10	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.127101096	2010	PUS10	2	60959694	A	G
rs13003464	20228799	150962	PUS10	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.127101096	2010	PUS10	2	60959694	A	G
rs1317209	20228799	54546	RNF186	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.12973957	2010	RNF186	1	19813543	G	A
rs1317209	20228799	54546	RNF186	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.12973957	2010	RNF186	1	19813543	G	A
rs1317209	20228799	23252	OTUD3	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.129468128	2010	RNF186	1	19813543	G	A
rs1317209	20228799	30814	PLA2G2E	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.007101096	2010	RNF186	1	19813543	G	A
rs13361189	19491842	345611	IRGM	umls:C0009324	BeFree	In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.	0.123995683	2009	NA	5	150843825	T	C
rs13361189	19491842	55054	ATG16L1	umls:C0009324	BeFree	In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.	0.03283333	2009	NA	5	150843825	T	C
rs1405655	21245992	4790	NFKB1	umls:C0009324	BeFree	Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.	0.1312586	2011	NR1H2	19	50379362	T	C
rs1456893	21830272	149233	IL23R	umls:C0009324	BeFree	Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated.	0.326936272	2011	NA	7	50230076	G	A
rs1456893	21830272	4485	MST1	umls:C0009324	BeFree	Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated.	0.254092571	2011	NA	7	50230076	G	A
rs1523127	21245992	4790	NFKB1	umls:C0009324	BeFree	Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.	0.1312586	2011	NR1I2	3	119782192	C	A
rs1545620	21648020	4650	MYO9B	umls:C0009324	BeFree	In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02).	0.006991475	2011	MYO9B	19	17192965	T	G
rs1545620	21648020	149233	IL23R	umls:C0009324	BeFree	In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02).	0.326936272	2011	MYO9B	19	17192965	T	G
rs1554973	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	NA	9	117718534	T	C
rs1554973	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	NA	9	117718534	T	C
rs1554973	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	NA	9	117718534	T	C
rs1554973	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	NA	9	117718534	T	C
rs1554973	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	NA	9	117718534	T	C
rs1554973	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	NA	9	117718534	T	C
rs1554973	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	NA	9	117718534	T	C
rs1554973	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	NA	9	117718534	T	C
rs1554973	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	NA	9	117718534	T	C
rs1554973	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	NA	9	117718534	T	C
rs1554973	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	NA	9	117718534	T	C
rs1554973	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	NA	9	117718534	T	C
rs1554973	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	NA	9	117718534	T	C
rs1554973	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	NA	9	117718534	T	C
rs1554973	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	NA	9	117718534	T	C
rs1554973	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	NA	9	117718534	T	C
rs1554973	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	NA	9	117718534	T	C
rs1554973	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	NA	9	117718534	T	C
rs1554973	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	NA	9	117718534	T	C
rs1554973	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	NA	9	117718534	T	C
rs1554973	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	NA	9	117718534	T	C
rs1554973	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	NA	9	117718534	T	C
rs1554973	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	NA	9	117718534	T	C
rs1554973	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	NA	9	117718534	T	C
rs1554973	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	NA	9	117718534	T	C
rs1554973	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	NA	9	117718534	T	C
rs1554973	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	NA	9	117718534	T	C
rs1554973	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	NA	9	117718534	T	C
rs1558744	19122664	50616	IL22	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.004810009	2009	NA	12	68110812	G	A
rs1558744	19122664	3458	IFNG	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.011530042	2009	NA	12	68110812	G	A
rs1558744	20228799	55801	IL26	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.12764398	2010	NA	12	68110812	G	A
rs1558744	19122664	55801	IL26	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12764398	2009	NA	12	68110812	G	A
rs1558744	20228799	3458	IFNG	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.011530042	2010	NA	12	68110812	G	A
rs1561570	22685416	6579	SLCO1A2	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	OPTN	10	13113726	T	C
rs1561570	22685416	22915	MMRN1	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	OPTN	10	13113726	T	C
rs1561570	22685416	3663	IRF5	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.121357209	2012	OPTN	10	13113726	T	C
rs16940202	21297633	3394	IRF8	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	NA	16	85980635	T	C
rs1695	21234761	2950	GSTP1	umls:C0009324	BeFree	XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.	0.003181358	2011	GSTP1	11	67585218	A	G
rs1701704	22685416	6579	SLCO1A2	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	IKZF4;LOC105369781	12	56018703	T	G
rs1701704	22685416	22915	MMRN1	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	IKZF4;LOC105369781	12	56018703	T	G
rs1701704	22685416	3663	IRF5	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.121357209	2012	IKZF4;LOC105369781	12	56018703	T	G
rs17085007	19915573	219333	USP12	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.002367032	2009	NA	13	26957130	T	C
rs17085007	21297633	2835	GPR12	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.004734064	2011	NA	13	26957130	T	C
rs17085007	19915573	2835	GPR12	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.004734064	2009	NA	13	26957130	T	C
rs17207986	20848476	9966	TNFSF15	umls:C0009324	BeFree	Comparison of the MR-UC subjects with healthy controls confirmed the contribution of the major histocompatibility complex to severe UC (peak association: rs17207986, P = 1.4 × 10(-16)) and provided genome-wide suggestive association at the TNFSF15 (TL1A) locus (peak association: rs11554257, P = 1.4 × 10(-6)).	0.259445464	2010	NA	6	32111790	T	C
rs1728785	19915572	999	CDH1	umls:C0009324	GAD	[Of note, CDH1 has recently been associated with susceptibility to colorectal cancer, an established complication of longstanding ulcerative colitis.]	0.124267125	2009	ZFP90	16	68557327	A	C
rs1728785	19915572	146198	ZFP90	umls:C0009324	GWASCAT	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	0.120271442	2009	ZFP90	16	68557327	A	C
rs1728785	23128233	146198	ZFP90	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.120271442	2012	ZFP90	16	68557327	A	C
rs1736135	20228799	8204	NRIP1	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.004734064	2010	LOC101927745	21	15432901	T	C
rs17375018	21648020	149233	IL23R	umls:C0009324	BeFree	In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02).	0.326936272	2011	IL23R	1	67189464	G	A
rs17375018	21648020	4650	MYO9B	umls:C0009324	BeFree	In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02).	0.006991475	2011	IL23R	1	67189464	G	A
rs1738074	22592522	117289	TAGAP	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000271442	2012	TAGAP;LOC105378082	6	159044945	T	C
rs1738074	22592522	102723996	LOC102723996	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000542884	2012	TAGAP;LOC105378082	6	159044945	T	C
rs1738074	22592522	9844	ELMO1	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000271442	2012	TAGAP;LOC105378082	6	159044945	T	C
rs17388568	21297633	132612	ADAD1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.125005506	2011	ADAD1	4	122408207	G	A
rs17388568	21297633	132612	ADAD1	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.125005506	2011	ADAD1	4	122408207	G	A
rs1799977	18200512	4292	MLH1	umls:C0009324	BeFree	Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis.	0.012268423	2008	MLH1	3	37012077	A	C,G
rs1799977	19371218	4292	MLH1	umls:C0009324	BeFree	I219V polymorphism in hMLH1 gene in patients affected with ulcerative colitis.	0.012268423	2009	MLH1	3	37012077	A	C,G
rs1800629	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	TNF	6	31575254	G	A
rs1800629	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	TNF	6	31575254	G	A
rs1800629	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	TNF	6	31575254	G	A
rs1800629	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	TNF	6	31575254	G	A
rs1800629	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	TNF	6	31575254	G	A
rs1800629	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	TNF	6	31575254	G	A
rs1800629	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	TNF	6	31575254	G	A
rs1800629	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	TNF	6	31575254	G	A
rs1800629	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	TNF	6	31575254	G	A
rs1800629	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	TNF	6	31575254	G	A
rs1800629	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	TNF	6	31575254	G	A
rs1800629	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	TNF	6	31575254	G	A
rs1800629	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	TNF	6	31575254	G	A
rs1801274	19915573	2212	FCGR2A	umls:C0009324	GWASCAT	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.	0.248186863	2009	FCGR2A	1	161509955	A	G
rs1801274	21297633	2212	FCGR2A	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.248186863	2011	FCGR2A	1	161509955	A	G
rs1801274	19915573	2212	FCGR2A	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.248186863	2009	FCGR2A	1	161509955	A	G
rs1801274	21297633	2212	FCGR2A	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.248186863	2011	FCGR2A	1	161509955	A	G
rs1801275	11378820	3566	IL4R	umls:C0009324	BeFree	We did not find any significant correlation between a 32-bp deletion variant of CCR5 or a single nucleotide change A1902G (Gln576Arg) of IL4RA, and IBD phenotypes, with the exception that in the UC group homozygosity for the G1902 allele of IL4RA was less frequent (0.019 vs 0.049, P=0.038).	0.000542884	2001	IL4R	16	27363079	A	G
rs1801275	11378820	1234	CCR5	umls:C0009324	BeFree	We did not find any significant correlation between a 32-bp deletion variant of CCR5 or a single nucleotide change A1902G (Gln576Arg) of IL4RA, and IBD phenotypes, with the exception that in the UC group homozygosity for the G1902 allele of IL4RA was less frequent (0.019 vs 0.049, P=0.038).	0.001085767	2001	IL4R	16	27363079	A	G
rs1801282	23256116	5468	PPARG	umls:C0009324	BeFree	We were unable to replicate in a Caucasian cohort the recent association between PPARγ C161T and UC or between PPARγ Pro12Ala and an extensive UC phenotype in a Chinese population.	0.012897183	2013	PPARG	3	12351626	C	G
rs1801282	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	PPARG	3	12351626	C	G
rs1801282	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	PPARG	3	12351626	C	G
rs1801282	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	PPARG	3	12351626	C	G
rs1801282	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	PPARG	3	12351626	C	G
rs1801282	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	PPARG	3	12351626	C	G
rs1801282	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	PPARG	3	12351626	C	G
rs1801282	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	PPARG	3	12351626	C	G
rs1801282	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	PPARG	3	12351626	C	G
rs1801282	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	PPARG	3	12351626	C	G
rs1801282	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	PPARG	3	12351626	C	G
rs1801282	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	PPARG	3	12351626	C	G
rs1801282	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	PPARG	3	12351626	C	G
rs1801282	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	PPARG	3	12351626	C	G
rs1801394	21947961	4552	MTRR	umls:C0009324	BeFree	The variant allele and genotypic frequencies in MTHFR A1298C, MTR A2756G and MTRR A66G genes were significantly higher in patients with UC compared to healthy controls.	0.002909916	2012	MTRR;FASTKD3	5	7870860	A	G
rs1805087	18700049	4548	MTR	umls:C0009324	BeFree	Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.	0.005362824	2008	MTR	1	236885200	A	G
rs1805087	18700049	4524	MTHFR	umls:C0009324	BeFree	Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.	0.020650783	2008	MTR	1	236885200	A	G
rs1805192	23256116	5468	PPARG	umls:C0009324	BeFree	We were unable to replicate in a Caucasian cohort the recent association between PPARγ C161T and UC or between PPARγ Pro12Ala and an extensive UC phenotype in a Chinese population.	0.012897183	2013	PPARG	3	12379739	C	G
rs1816702	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	TLR2	4	153688371	T	C
rs1816702	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR2	4	153688371	T	C
rs1816702	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR2	4	153688371	T	C
rs1816702	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	TLR2	4	153688371	T	C
rs1816702	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	TLR2	4	153688371	T	C
rs1816702	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	TLR2	4	153688371	T	C
rs1816702	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR2	4	153688371	T	C
rs1816702	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	TLR2	4	153688371	T	C
rs1816702	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR2	4	153688371	T	C
rs1816702	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	TLR2	4	153688371	T	C
rs1816702	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR2	4	153688371	T	C
rs1816702	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR2	4	153688371	T	C
rs1816702	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR2	4	153688371	T	C
rs1816702	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	TLR2	4	153688371	T	C
rs1816702	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	TLR2	4	153688371	T	C
rs1816702	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR2	4	153688371	T	C
rs1816702	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	TLR2	4	153688371	T	C
rs1816702	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	TLR2	4	153688371	T	C
rs1816702	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR2	4	153688371	T	C
rs1816702	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR2	4	153688371	T	C
rs1816702	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR2	4	153688371	T	C
rs1816702	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR2	4	153688371	T	C
rs1816702	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR2	4	153688371	T	C
rs1816702	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	TLR2	4	153688371	T	C
rs1816702	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR2	4	153688371	T	C
rs1816702	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	TLR2	4	153688371	T	C
rs1816702	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	TLR2	4	153688371	T	C
rs1816702	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR2	4	153688371	T	C
rs181856615	20195480	56144	PCDHA4	umls:C0009324	BeFree	The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease.	0.000271442	2010	PCDHA9;PCDHA11;PCDHA10;PCDHA8;PCDHA7;PCDHA6;PCDHA5;PCDHA4;PCDHA3;PCDHA2;PCDHA1	5	140870462	G	A
rs1861494	25171510	3458	IFNG	umls:C0009324	BeFree	Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.	0.011530042	2015	IFNG	12	68157629	C	T
rs187084	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR9	3	52227015	A	G
rs187084	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR9	3	52227015	A	G
rs187084	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR9	3	52227015	A	G
rs187084	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR9	3	52227015	A	G
rs187084	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR9	3	52227015	A	G
rs187084	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR9	3	52227015	A	G
rs187084	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR9	3	52227015	A	G
rs187084	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR9	3	52227015	A	G
rs187084	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR9	3	52227015	A	G
rs187084	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR9	3	52227015	A	G
rs187084	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR9	3	52227015	A	G
rs187084	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR9	3	52227015	A	G
rs187084	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR9	3	52227015	A	G
rs187084	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR9	3	52227015	A	G
rs187084	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR9	3	52227015	A	G
rs1992950	20228799	23314	SATB2	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002367032	2010	SATB2	2	199425636	A	G
rs2032582	17260353	5243	ABCB1	umls:C0009324	BeFree	A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212 control subjects were investigated for the presence of MDR1 G2677T/A and C3435T polymorphisms.	0.054051573	2007	ABCB1	7	87531302	A	T,C
rs2032582	15685540	5243	ABCB1	umls:C0009324	BeFree	This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).	0.054051573	2005	ABCB1	7	87531302	A	T,C
rs2043211	21248762	3553	IL1B	umls:C0009324	BeFree	The stop allele of rs2043211 was associated with higher serum interleukin-1β levels only in female patients with UC (P = 0.027).	0.144069907	2011	CARD8	19	48234449	A	T
rs2066842	12115195	64127	NOD2	umls:C0009324	BeFree	A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed inflammatory bowel disease (IBD), 197 cases of AS associated with IBD (referred to as colitic spondylarthritis; comprising 78 with CD and 119 with ulcerative colitis [UC]), and 229 ethnically matched, healthy controls.	0.233979892	2002	NOD2	16	50710713	C	A,T
rs2066842	22426692	149233	IL23R	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.326936272	2012	NOD2	16	50710713	C	A,T
rs2066842	22426692	5771	PTPN2	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.129358507	2012	NOD2	16	50710713	C	A,T
rs2066842	24145928	64127	NOD2	umls:C0009324	BeFree	Recent studies from India have reported an association with UC and a single polymorphism (SNP) in CARD15/NOD2 (SNP5, rs2066842), which has not been reported in Caucasian UC cohorts.	0.233979892	2014	NOD2	16	50710713	C	A,T
rs2066842	22426692	64127	NOD2	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.233979892	2012	NOD2	16	50710713	C	A,T
rs2066843	21209938	64127	NOD2	umls:C0009324	BeFree	Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).	0.233979892	2010	NOD2	16	50711288	C	A,T
rs2066844	16485124	64127	NOD2	umls:C0009324	BeFree	We performed a limited DNA sequence analysis of the CARD15 gene in 89 patients with Crohn's disease (CD), 19 patients with ulcerative colitis (UC), and three patients with indeterminate colitis (IC), who were heterozygous carriers of one of the common CARD15 mutations [c.2104C>T (p.R702W), c.2722G>C (p.G908R), or c.3019_3020insC (p.Leu1007fsX1008)], the c.2462+10A>C variant, or of a new amino acid substitution in the 3'-end of exon 4.	0.233979892	2006	NOD2	16	50712015	C	T
rs2066844	16010583	7099	TLR4	umls:C0009324	BeFree	We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis.	0.034352361	2005	NOD2	16	50712015	C	T
rs2066844	21209938	64127	NOD2	umls:C0009324	BeFree	Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).	0.233979892	2010	NOD2	16	50712015	C	T
rs2066844	20082483	149233	IL23R	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.326936272	2010	NOD2	16	50712015	C	T
rs2066844	12115195	64127	NOD2	umls:C0009324	BeFree	A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed inflammatory bowel disease (IBD), 197 cases of AS associated with IBD (referred to as colitic spondylarthritis; comprising 78 with CD and 119 with ulcerative colitis [UC]), and 229 ethnically matched, healthy controls.	0.233979892	2002	NOD2	16	50712015	C	T
rs2066844	16010583	64127	NOD2	umls:C0009324	BeFree	We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis.	0.233979892	2005	NOD2	16	50712015	C	T
rs2066844	18680223	64127	NOD2	umls:C0009324	BeFree	NOD2/CARD15 R702W mutation was significantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03).	0.233979892	2008	NOD2	16	50712015	C	T
rs2066844	18680223	7099	TLR4	umls:C0009324	BeFree	To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.	0.034352361	2008	NOD2	16	50712015	C	T
rs2066844	12631669	64127	NOD2	umls:C0009324	BeFree	We investigated 198 sporadic CD patients, 46 probands with familial CD, 27 CD probands from mixed IBD families, 99 unrelated patients with ulcerative colitis (UC), and 300 control individuals for the occurrence of the CARD15 gene variants R702W, G908R, and 1007fs.	0.233979892	2003	NOD2	16	50712015	C	T
rs2066844	20082483	55054	ATG16L1	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.03283333	2010	NOD2	16	50712015	C	T
rs2066844	20082483	64127	NOD2	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.233979892	2010	NOD2	16	50712015	C	T
rs2066845	23709157	64127	NOD2	umls:C0009324	BeFree	Three common NOD2 mutations are associated with Crohn's disease (p=5.08×10(-7), 1.67×10(-6), and 1.87×10(-2) for 1007fs, R720W, and G908R, respectively), but not with ulcerative colitis (p=0.1046, 0.1269, and 0.8929, respectively).	0.233979892	2013	NOD2	16	50722629	G	C,T
rs2066845	21209938	64127	NOD2	umls:C0009324	BeFree	Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).	0.233979892	2010	NOD2	16	50722629	G	C,T
rs2066845	20082483	149233	IL23R	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.326936272	2010	NOD2	16	50722629	G	C,T
rs2066845	21830272	4485	MST1	umls:C0009324	BeFree	Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated.	0.254092571	2011	NOD2	16	50722629	G	C,T
rs2066845	18942754	3558	IL2	umls:C0009324	BeFree	Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population.	0.013072817	2009	NOD2	16	50722629	G	C,T
rs2066845	21830272	149233	IL23R	umls:C0009324	BeFree	Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated.	0.326936272	2011	NOD2	16	50722629	G	C,T
rs2066845	18942754	3553	IL1B	umls:C0009324	BeFree	Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population.	0.144069907	2009	NOD2	16	50722629	G	C,T
rs2066845	12115195	64127	NOD2	umls:C0009324	BeFree	A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed inflammatory bowel disease (IBD), 197 cases of AS associated with IBD (referred to as colitic spondylarthritis; comprising 78 with CD and 119 with ulcerative colitis [UC]), and 229 ethnically matched, healthy controls.	0.233979892	2002	NOD2	16	50722629	G	C,T
rs2066845	20082483	55054	ATG16L1	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.03283333	2010	NOD2	16	50722629	G	C,T
rs2066845	18942754	64127	NOD2	umls:C0009324	BeFree	Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population.	0.233979892	2009	NOD2	16	50722629	G	C,T
rs2066845	18680223	7099	TLR4	umls:C0009324	BeFree	To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.	0.034352361	2008	NOD2	16	50722629	G	C,T
rs2066845	20082483	64127	NOD2	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.233979892	2010	NOD2	16	50722629	G	C,T
rs2066845	16485124	64127	NOD2	umls:C0009324	BeFree	We performed a limited DNA sequence analysis of the CARD15 gene in 89 patients with Crohn's disease (CD), 19 patients with ulcerative colitis (UC), and three patients with indeterminate colitis (IC), who were heterozygous carriers of one of the common CARD15 mutations [c.2104C>T (p.R702W), c.2722G>C (p.G908R), or c.3019_3020insC (p.Leu1007fsX1008)], the c.2462+10A>C variant, or of a new amino acid substitution in the 3'-end of exon 4.	0.233979892	2006	NOD2	16	50722629	G	C,T
rs2066845	18942754	7099	TLR4	umls:C0009324	BeFree	Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population.	0.034352361	2009	NOD2	16	50722629	G	C,T
rs2066845	18942754	7097	TLR2	umls:C0009324	BeFree	Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population.	0.011996981	2009	NOD2	16	50722629	G	C,T
rs2066845	12631669	64127	NOD2	umls:C0009324	BeFree	We investigated 198 sporadic CD patients, 46 probands with familial CD, 27 CD probands from mixed IBD families, 99 unrelated patients with ulcerative colitis (UC), and 300 control individuals for the occurrence of the CARD15 gene variants R702W, G908R, and 1007fs.	0.233979892	2003	NOD2	16	50722629	G	C,T
rs2066847	20082483	149233	IL23R	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.326936272	2010	NOD2	16	50729867	-	C
rs2066847	20082483	55054	ATG16L1	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.03283333	2010	NOD2	16	50729867	-	C
rs2066847	20082483	64127	NOD2	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.233979892	2010	NOD2	16	50729867	-	C
rs2066847	21209938	64127	NOD2	umls:C0009324	BeFree	Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).	0.233979892	2010	NOD2	16	50729867	-	C
rs2076756	21209938	64127	NOD2	umls:C0009324	BeFree	Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).	0.233979892	2010	NOD2	16	50722970	A	G
rs2108225	19915573	1811	SLC26A3	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.132106602	2009	NA	7	107812658	G	A
rs2155219	21297633	56946	C11orf30	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	NA	11	76588150	G	T
rs2158836	19122664	1738	DLD	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.004734064	2009	LAMB1	7	107940394	A	G
rs2158836	19122664	1811	SLC26A3	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.132106602	2009	LAMB1	7	107940394	A	G
rs2158836	19122664	3912	LAMB1	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12764398	2009	LAMB1	7	107940394	A	G
rs2201841	20228799	149233	IL23R	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.326936272	2010	IL23R	1	67228519	A	G
rs2201841	24415875	50941	IBD5	umls:C0009324	BeFree	The IL23R rs2201841 homozygous genotype and IBD5 carrier status together did not confer susceptibility for UC.	0.019912403	2013	IL23R	1	67228519	A	G
rs2201841	24415875	149233	IL23R	umls:C0009324	BeFree	The IL23R rs2201841 homozygous genotype and IBD5 carrier status together did not confer susceptibility for UC.	0.326936272	2013	IL23R	1	67228519	A	G
rs2241057	23977348	56603	CYP26B1	umls:C0009324	BeFree	Cytochrome P450 26 B1 (CYP26B1) is involved in the degradation of retinoic acid and the polymorphism rs2241057 has an elevated catabolic function of retinoic acid, why we hypothesized that the rs2241057 polymorphism may affect the risk of Crohn's disease (CD) and Ulcerative Colitis (UC).	0.000271442	2013	CYP26B1	2	72134831	A	G
rs2241879	22457781	55054	ATG16L1	umls:C0009324	BeFree	Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC.	0.03283333	2012	ATG16L1;SCARNA5	2	233274822	G	A
rs2241880	25159710	55054	ATG16L1	umls:C0009324	BeFree	In addition, the carriage of T300A variant alleles conferred a protective effect in UC.	0.03283333	2014	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	20222171	55054	ATG16L1	umls:C0009324	BeFree	The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.	0.03283333	2010	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	19491842	345611	IRGM	umls:C0009324	BeFree	In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.	0.123995683	2009	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	20082483	55054	ATG16L1	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.03283333	2010	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	20082483	149233	IL23R	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.326936272	2010	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	19491842	55054	ATG16L1	umls:C0009324	BeFree	In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.	0.03283333	2009	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	18366306	55054	ATG16L1	umls:C0009324	BeFree	With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.	0.03283333	2008	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	20082483	64127	NOD2	umls:C0009324	BeFree	One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).	0.233979892	2010	ATG16L1;SCARNA5	2	233274722	A	G
rs2241880	18671817	55054	ATG16L1	umls:C0009324	BeFree	We confirm the strong association between T300A and CD, specifically ileal subphenotype, and also report the first strong association of this variant with UC.	0.03283333	2008	ATG16L1;SCARNA5	2	233274722	A	G
rs2246901	17058067	4583	MUC2	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.081628651	2006	MUC4	3	195762138	C	A
rs2246901	17058067	56667	MUC13	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.000271442	2006	MUC4	3	195762138	C	A
rs2246901	17058067	4585	MUC4	umls:C0009324	BeFree	Allelic discrimination screening obtained statistically significant associations for the MUC2-V116M (P = 0.003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC.	0.000542884	2006	MUC4	3	195762138	C	A
rs2275913	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	IL17A	6	52186235	G	A
rs2275913	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	IL17A	6	52186235	G	A
rs2275913	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	IL17A	6	52186235	G	A
rs2275913	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	IL17A	6	52186235	G	A
rs2275913	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	IL17A	6	52186235	G	A
rs2275913	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	IL17A	6	52186235	G	A
rs2275913	22955700	3605	IL17A	umls:C0009324	BeFree	Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.	0.007795869	2012	IL17A	6	52186235	G	A
rs2275913	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	IL17A	6	52186235	G	A
rs2275913	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	IL17A	6	52186235	G	A
rs2275913	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	IL17A	6	52186235	G	A
rs2275913	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	IL17A	6	52186235	G	A
rs2275913	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	IL17A	6	52186235	G	A
rs2275913	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	IL17A	6	52186235	G	A
rs2275913	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	IL17A	6	52186235	G	A
rs2275913	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	IL17A	6	52186235	G	A
rs2275913	22028838	3605	IL17A	umls:C0009324	BeFree	The single nucleotide polymorphism (SNP), rs2275913, in the promoter region of the IL-17 gene is associated with susceptibility to ulcerative colitis.	0.007795869	2011	IL17A	6	52186235	G	A
rs2275913	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	IL17A	6	52186235	G	A
rs2289308	16494592	9231	DLG5	umls:C0009324	BeFree	Six DLG5 variants (p.R30Q, p.P1371Q, p.G1066G, rs2289308, DLG_e26, p.D1507D) were genotyped in two study populations: (1) German IBD patients (CD n = 250; ulcerative colitis (UC) n = 150) and German healthy controls (n = 422); (2) Hungarian IBD patients (CD n = 144; UC n = 124) and Hungarian healthy controls (n = 205).	0.007177041	2006	DLG5	10	77819493	G	A
rs2297441	21297633	8771	TNFRSF6B	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002638474	2011	TNFRSF6B;RTEL1;RTEL1-TNFRSF6B	20	63696229	G	A
rs2297441	21297633	51750	RTEL1	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.12	2011	TNFRSF6B;RTEL1;RTEL1-TNFRSF6B	20	63696229	G	A
rs2297441	21297633	100533107	RTEL1-TNFRSF6B	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.12	2011	TNFRSF6B;RTEL1;RTEL1-TNFRSF6B	20	63696229	G	A
rs2298428	22592522	7332	UBE2L3	umls:C0009324	BeFree	In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44 × 10(-5), OR: 2.59) associated with pediatric UC and CD, respectively.	0.000542884	2012	YDJC	22	21628603	C	T
rs2301436	22269120	9034	CCRL2	umls:C0009324	BeFree	Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.	0.001085767	2012	FGFR1OP	6	167024500	C	T
rs2305480	20228799	55876	GSDMB	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.125005506	2010	GSDMB	17	39905943	G	A
rs2305480	20228799	55876	GSDMB	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.125005506	2010	GSDMB	17	39905943	G	A
rs2305480	20228799	94103	ORMDL3	umls:C0009324	GAD	[After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3).]	0.123181358	2010	GSDMB	17	39905943	G	A
rs2310173	21297633	7850	IL1R2	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.122367032	2011	NA	2	102047167	T	G
rs2359952	24837172	5788	PTPRC	umls:C0009324	GWASCAT	Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.	0.12	2015	PTPRC	1	198687278	A	G
rs2395185	22694930	3122	HLA-DRA	umls:C0009324	BeFree	The minor allele T of rs2395185 in HLA-DRA is the risk allele for asthma but the protective allele for ulcerative colitis.	0.012106602	2012	NA	6	32465390	G	T
rs2395185	19122664	56244	BTNL2	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.017469426	2009	NA	6	32465390	G	T
rs2395185	19122664	3119	HLA-DQB1	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.007729856	2009	NA	6	32465390	G	T
rs2395185	19122664	3122	HLA-DRA	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.012106602	2009	NA	6	32465390	G	T
rs2395185	19122664	3117	HLA-DQA1	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.124734064	2009	NA	6	32465390	G	T
rs242557	22685416	3663	IRF5	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.121357209	2012	MAPT	17	45942346	G	A
rs242557	22685416	6579	SLCO1A2	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	MAPT	17	45942346	G	A
rs242557	22685416	22915	MMRN1	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	MAPT	17	45942346	G	A
rs2430561	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	IFNG	12	68158742	T	A
rs2430561	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	IFNG	12	68158742	T	A
rs2430561	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	IFNG	12	68158742	T	A
rs2430561	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	IFNG	12	68158742	T	A
rs2430561	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	IFNG	12	68158742	T	A
rs2430561	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	IFNG	12	68158742	T	A
rs2430561	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	IFNG	12	68158742	T	A
rs2430561	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	IFNG	12	68158742	T	A
rs2430561	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	IFNG	12	68158742	T	A
rs2430561	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	IFNG	12	68158742	T	A
rs2430561	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	IFNG	12	68158742	T	A
rs2430561	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	IFNG	12	68158742	T	A
rs2430561	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	IFNG	12	68158742	T	A
rs2430561	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	IFNG	12	68158742	T	A
rs2430561	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	IFNG	12	68158742	T	A
rs2476601	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	23974994	26191	PTPN22	umls:C0009324	BeFree	SNP-SNP interaction analyses showed that the combination of SNPs in the PTPN22 (rs2476601) and C13orf31 (rs3764147) genes increase the risk for UC.	0.009001189	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	23974994	144811	LACC1	umls:C0009324	BeFree	SNP-SNP interaction analyses showed that the combination of SNPs in the PTPN22 (rs2476601) and C13orf31 (rs3764147) genes increase the risk for UC.	0.002638474	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2488457	23456301	26191	PTPN22	umls:C0009324	BeFree	Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.	0.009001189	2013	PTPN22;AP4B1-AS1	1	113872746	G	C,A
rs2542151	22426692	149233	IL23R	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.326936272	2012	NA	18	12779948	G	T
rs2542151	22426692	64127	NOD2	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.233979892	2012	NA	18	12779948	G	T
rs2542151	22426692	5771	PTPN2	umls:C0009324	BeFree	The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.	0.129358507	2012	NA	18	12779948	G	T
rs2542151	22021207	5771	PTPN2	umls:C0009324	BeFree	The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.	0.129358507	2012	NA	18	12779948	G	T
rs2542151	22457781	55054	ATG16L1	umls:C0009324	BeFree	Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC.	0.03283333	2012	NA	18	12779948	G	T
rs254560	23128233	100996485	C5orf66	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	C5orf66	5	135107916	G	A
rs254560	21297633	5307	PITX1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	C5orf66	5	135107916	G	A
rs254560	21297633	100996485	C5orf66	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.12	2011	C5orf66	5	135107916	G	A
rs25487	21234761	2950	GSTP1	umls:C0009324	BeFree	XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.	0.003181358	2011	XRCC1	19	43551574	T	C
rs25487	22193858	401637	OR7E26P	umls:C0009324	BeFree	The frequency of genotype Arg399Gln (heterozygous) of XRCC1 gene was significantly higher in patients with UC than the controls (odds ratio [OR] 1.73; 95% confidence interval [CI] 1.13-2.64; p = 0.01).	0.000271442	2012	XRCC1	19	43551574	T	C
rs2569190	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	23049772	929	CD14	umls:C0009324	BeFree	Expanding previous results of individual studies, our findings demonstrated that CD14 gene C-260T polymorphism might be a promising candidate marker in susceptibility to UC, especially in Asians.	0.030638051	2012	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	CD14;TMCO6	5	140633331	A	G
rs2569190	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	CD14;TMCO6	5	140633331	A	G
rs267939	21297633	1611	DAP	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.242638474	2011	DAP	5	10752203	C	T
rs267939	21297633	1611	DAP	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.242638474	2011	DAP	5	10752203	C	T
rs2695121	21245992	4790	NFKB1	umls:C0009324	BeFree	Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.	0.1312586	2011	NR1H2	19	50377484	T	C
rs2762051	24911414	60498	IGAN1	umls:C0009324	BeFree	These four variants are implicated in complex phenotypes such as ulcerative colitis and AIDS progression disease (rs10491434), Celiac disease (rs2762051), Crohn's disease, IgA nephropathy and early-onset inflammatory bowel disease (rs713875) and height (rs6569648).	0.000271442	2014	DLEU1	13	50261579	C	T
rs2816958	23128233	2494	NR5A2	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.120271442	2012	NR5A2	1	200132792	A	G
rs28362491	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	21245992	4790	NFKB1	umls:C0009324	BeFree	Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.	0.1312586	2011	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28362491	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	NFKB1;LOC105377621	4	102500998	ATTG	-
rs28374715	23128233	11261	CHP1	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	CHP1	15	41271752	A	G
rs2838519	21297633	8209	C21orf33	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.122638474	2011	LOC105377139	21	44195140	G	A
rs2838519	21297633	8209	C21orf33	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.122638474	2011	LOC105377139	21	44195140	G	A
rs2858829	25082827	441168	FAM26F	umls:C0009324	BeFree	SNP rs2858829 lies in an intergenic region and is a strong cis-eQTL for FAM26F gene, a gene that is shown to be selectively upregulated in UC colonic mucosa with active inflammation.	0.000271442	2015	NA	6	116447754	A	G
rs2870946	19122664	55801	IL26	umls:C0009324	GWASCAT	Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.	0.12764398	2009	IL26;LOC105369818	12	68202881	T	C
rs2870946	19122664	55801	IL26	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12764398	2009	IL26;LOC105369818	12	68202881	T	C
rs2872507	22694930	55876	GSDMB	umls:C0009324	BeFree	The minor allele A of rs2872507 in GSDMB is the protective allele for asthma but the risk allele for rheumatoid arthritis, Crohn disease, and ulcerative colitis.	0.125005506	2012	NA	17	39884510	G	A
rs2872507	21297633	124626	ZPBP2	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.004734064	2011	NA	17	39884510	G	A
rs2910164	20848167	574501	MIR499A	umls:C0009324	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.	0.000271442	2011	LOC285628;MIR146A	5	160485411	C	G
rs2910164	20848167	406938	MIR146A	umls:C0009324	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.	0.000542884	2011	LOC285628;MIR146A	5	160485411	C	G
rs3024493	19915572	3586	IL10	umls:C0009324	GWASCAT	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	0.294635894	2009	IL10	1	206770623	C	A
rs3024493	20228798	3586	IL10	umls:C0009324	GWASCAT	Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).	0.294635894	2010	IL10	1	206770623	C	A
rs3024505	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	NA	1	206766559	G	A
rs3024505	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	NA	1	206766559	G	A
rs3024505	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	NA	1	206766559	G	A
rs3024505	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	NA	1	206766559	G	A
rs3024505	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	NA	1	206766559	G	A
rs3024505	20228799	29949	IL19	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002638474	2010	NA	1	206766559	G	A
rs3024505	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	NA	1	206766559	G	A
rs3024505	20509889	3586	IL10	umls:C0009324	BeFree	The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study.	0.294635894	2010	NA	1	206766559	G	A
rs3024505	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	NA	1	206766559	G	A
rs3024505	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	NA	1	206766559	G	A
rs3024505	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	NA	1	206766559	G	A
rs3024505	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	NA	1	206766559	G	A
rs3024505	20509889	3586	IL10	umls:C0009324	GAD	[The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study.]	0.294635894	2010	NA	1	206766559	G	A
rs3024505	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	NA	1	206766559	G	A
rs3024505	23348120	3586	IL10	umls:C0009324	BeFree	Only one SNP, rs3024505 (Chr 1q32.1, upstream of IL10), was associated with susceptibility to UC.	0.294635894	2013	NA	1	206766559	G	A
rs3024505	18836448	3586	IL10	umls:C0009324	GAD	[Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.]	0.294635894	2008	NA	1	206766559	G	A
rs3024505	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	NA	1	206766559	G	A
rs3024505	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	NA	1	206766559	G	A
rs3135932	18800073	3587	IL10RA	umls:C0009324	BeFree	The IL-10R1 S138G loss-of-function allele and ulcerative colitis.	0.005634266	2009	IL10RA	11	117993348	A	G
rs3135932	18800073	6774	STAT3	umls:C0009324	BeFree	In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility.	0.135254284	2009	IL10RA	11	117993348	A	G
rs3135932	18800073	3586	IL10	umls:C0009324	BeFree	In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility.	0.294635894	2009	IL10RA	11	117993348	A	G
rs3135932	18800073	6772	STAT1	umls:C0009324	BeFree	In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility.	0.000542884	2009	IL10RA	11	117993348	A	G
rs3194051	21297633	3575	IL7R	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.24	2011	IL7R	5	35876172	A	G
rs3197999	25082827	4485	MST1	umls:C0009324	GWASCAT	A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.	0.254092571	2015	MST1	3	49684099	G	A
rs3197999	19079170	4485	MST1	umls:C0009324	BeFree	We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage-stimulating 1 (MST1) gene (P-value 3.62 x 10(-6)) that accounts for the association signal, and shows association with both CD and UC.	0.254092571	2008	MST1	3	49684099	G	A
rs3197999	20024904	4485	MST1	umls:C0009324	BeFree	BSN and MST1 were significantly associated with either CD (P(rs9858542) 2.5 x 10(-7); P(rs3197999) 3.9 x 10(-7)), and UC (P(rs9858542) = 3.1 x 10(-4); P(rs3197999) = 8 x 10(-4)).	0.254092571	2010	MST1	3	49684099	G	A
rs3197999	20228799	4485	MST1	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.254092571	2010	MST1	3	49684099	G	A
rs3197999	19944697	151306	GPBAR1	umls:C0009324	BeFree	Of 15 established ulcerative colitis susceptibility loci, significant replication was obtained at chromosomes 2q35 and 3p21 (rs12612347: OR, 1.26; 95% CI, 1.06-1.50; and rs3197999: OR, 1.22; 95% CI, 1.02-1.47, respectively), with circumstantial evidence supporting the G-protein-coupled bile acid receptor 1 and macrophage-stimulating 1, respectively, as the likely disease genes.	0.002909916	2010	MST1	3	49684099	G	A
rs3197999	20228799	4485	MST1	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.254092571	2010	MST1	3	49684099	G	A
rs33972313	24284447	27034	ACAD8	umls:C0009324	BeFree	Genomic DNA samples from patients with CD (n = 162) and UC (n = 149) from the Manitoba IBD Cohort Study and ethnically matched controls (n = 142) were genotyped for 3 SLC23A1 polymorphisms (rs6596473, rs33972313, and rs10063949) by using TaqMan assays.	0.010043349	2014	SLC23A1	5	139379813	C	T
rs352139	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	TLR9	3	52224356	T	C
rs352139	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR9	3	52224356	T	C
rs352139	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	TLR9	3	52224356	T	C
rs352139	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR9	3	52224356	T	C
rs352139	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	TLR9	3	52224356	T	C
rs352139	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR9	3	52224356	T	C
rs352139	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	TLR9	3	52224356	T	C
rs352139	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR9	3	52224356	T	C
rs352139	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR9	3	52224356	T	C
rs352139	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	TLR9	3	52224356	T	C
rs352139	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	TLR9	3	52224356	T	C
rs352139	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR9	3	52224356	T	C
rs352139	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR9	3	52224356	T	C
rs352139	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR9	3	52224356	T	C
rs352139	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	TLR9	3	52224356	T	C
rs352139	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	TLR9	3	52224356	T	C
rs352139	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	TLR9	3	52224356	T	C
rs352139	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR9	3	52224356	T	C
rs352139	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR9	3	52224356	T	C
rs352139	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR9	3	52224356	T	C
rs352139	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR9	3	52224356	T	C
rs352139	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	TLR9	3	52224356	T	C
rs352139	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	TLR9	3	52224356	T	C
rs352139	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	TLR9	3	52224356	T	C
rs352139	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR9	3	52224356	T	C
rs352139	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR9	3	52224356	T	C
rs352139	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR9	3	52224356	T	C
rs352139	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	TLR9	3	52224356	T	C
rs352140	19455129	50941	IBD5	umls:C0009324	BeFree	The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.	0.019912403	2009	TLR9	3	52222681	C	A,T
rs352140	19455129	9231	DLG5	umls:C0009324	BeFree	The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.	0.007177041	2009	TLR9	3	52222681	C	A,T
rs35675666	21297633	11315	PARK7	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.122367032	2011	PARK7	1	7961913	G	C,T
rs35675666	21297633	11315	PARK7	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.122367032	2011	PARK7	1	7961913	G	C,T
rs35873774	18775308	7495	XBP1P1	umls:C0009324	BeFree	An association of XBP1 variants with both forms of human IBD (Crohn's disease and ulcerative colitis) was identified and replicated (rs35873774; p value 1.6 x 10(-5)) with novel, private hypomorphic variants identified as susceptibility factors.	0.000542884	2008	XBP1	22	28795944	A	G
rs361525	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TNF	6	31575324	G	A
rs361525	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TNF	6	31575324	G	A
rs361525	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TNF	6	31575324	G	A
rs361525	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TNF	6	31575324	G	A
rs361525	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TNF	6	31575324	G	A
rs361525	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TNF	6	31575324	G	A
rs361525	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TNF	6	31575324	G	A
rs361525	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TNF	6	31575324	G	A
rs361525	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TNF	6	31575324	G	A
rs361525	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TNF	6	31575324	G	A
rs361525	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TNF	6	31575324	G	A
rs361525	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TNF	6	31575324	G	A
rs361525	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TNF	6	31575324	G	A
rs361525	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TNF	6	31575324	G	A
rs361525	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TNF	6	31575324	G	A
rs371209985	23709157	64127	NOD2	umls:C0009324	BeFree	Three common NOD2 mutations are associated with Crohn's disease (p=5.08×10(-7), 1.67×10(-6), and 1.87×10(-2) for 1007fs, R720W, and G908R, respectively), but not with ulcerative colitis (p=0.1046, 0.1269, and 0.8929, respectively).	0.233979892	2013	WDHD1	14	54957612	C	T
rs3746444	20848167	406938	MIR146A	umls:C0009324	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.	0.000542884	2011	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3746444	20848167	574501	MIR499A	umls:C0009324	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.	0.000271442	2011	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3748067	22955700	3605	IL17A	umls:C0009324	BeFree	Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.	0.007795869	2012	IL17A	6	52190541	C	T
rs376377228	18088064	149233	IL23R	umls:C0009324	BeFree	Given the association of IL23R with inflammatory bowel disease (IBD), we characterized the role of IL-17F in IBD including its intestinal gene expression and the effect of the IL17F p.His161Arg polymorphism on disease susceptibility and phenotype of Crohn's disease (CD) and ulcerative colitis (UC).	0.326936272	2008	IL23R	1	67182950	A	G
rs3764147	23974994	144811	LACC1	umls:C0009324	BeFree	SNP-SNP interaction analyses showed that the combination of SNPs in the PTPN22 (rs2476601) and C13orf31 (rs3764147) genes increase the risk for UC.	0.002638474	2014	LACC1	13	43883789	A	G
rs3764147	23974994	26191	PTPN22	umls:C0009324	BeFree	SNP-SNP interaction analyses showed that the combination of SNPs in the PTPN22 (rs2476601) and C13orf31 (rs3764147) genes increase the risk for UC.	0.009001189	2014	LACC1	13	43883789	A	G
rs3774959	23128233	4790	NFKB1	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.1312586	2012	NFKB1	4	102589957	G	A
rs3789243	17828778	5243	ABCB1	umls:C0009324	BeFree	In patients with extensive UC a significantly different distribution of genotypes of the MDR1 G/A change located in intron 3 (rs3789243) was observed between carriers/noncarriers of the -25385T risk allele (P = 0.005).	0.054051573	2007	ABCB1	7	87591570	A	G
rs3804099	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR2	4	153703504	T	C
rs3804099	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR2	4	153703504	T	C
rs3804099	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR2	4	153703504	T	C
rs3804099	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR2	4	153703504	T	C
rs3804099	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR2	4	153703504	T	C
rs3804099	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR2	4	153703504	T	C
rs3804099	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR2	4	153703504	T	C
rs3804099	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR2	4	153703504	T	C
rs3804099	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR2	4	153703504	T	C
rs3804099	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR2	4	153703504	T	C
rs3804099	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR2	4	153703504	T	C
rs3804099	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR2	4	153703504	T	C
rs3804099	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR2	4	153703504	T	C
rs3804099	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR2	4	153703504	T	C
rs3804099	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR2	4	153703504	T	C
rs3806308	19122664	54546	RNF186	umls:C0009324	GWASCAT	Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.	0.12973957	2009	RNF186	1	19816373	C	T
rs3806308	19122664	54546	RNF186	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12973957	2009	RNF186	1	19816373	C	T
rs386493716	22193858	401637	OR7E26P	umls:C0009324	BeFree	The frequency of genotype Arg399Gln (heterozygous) of XRCC1 gene was significantly higher in patients with UC than the controls (odds ratio [OR] 1.73; 95% confidence interval [CI] 1.13-2.64; p = 0.01).	0.000271442	2012	NA	NA	NA	NA	NA
rs386493716	21234761	2950	GSTP1	umls:C0009324	BeFree	XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.	0.003181358	2011	NA	NA	NA	NA	NA
rs386513644	20195480	1268	CNR1	umls:C0009324	BeFree	The CNR1 p.Thr453Thr polymorphism appears to modulate UC susceptibility and the CD phenotype.	0.002638474	2010	NA	NA	NA	NA	NA
rs386513644	20195480	56144	PCDHA4	umls:C0009324	BeFree	The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease.	0.000271442	2010	NA	NA	NA	NA	NA
rs3939286	23634226	90865	IL33	umls:C0009324	BeFree	Upon genotype-phenotype evaluation, an increased frequency of extensive colitis in adult UC (P = 0.019) and in steroid-responsive pediatric patients (P = 0.024) carrying the IL-33 rs3939286 risk genotype, was observed.	0.001628651	2013	NA	9	6210099	T	C
rs4077515	20228799	64170	CARD9	umls:C0009324	GWASCAT	Genome-wide association identifies multiple ulcerative colitis susceptibility loci.	0.250282454	2010	CARD9	9	136372044	C	T
rs4077515	20228799	64170	CARD9	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.250282454	2010	CARD9	9	136372044	C	T
rs4149570	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	TNFRSF1A	12	6342424	A	C
rs4149570	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TNFRSF1A	12	6342424	A	C
rs4151657	24837172	629	CFB	umls:C0009324	GWASCAT	Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.	0.120271442	2015	CFB	6	31949763	T	C
rs4246905	21297633	9966	TNFSF15	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.259445464	2011	TNFSF15	9	114790969	T	C
rs4246905	21297633	9966	TNFSF15	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.259445464	2011	TNFSF15	9	114790969	T	C
rs4251961	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	IL1RN	2	113116890	T	C
rs4251961	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	IL1RN	2	113116890	T	C
rs4358188	21272798	671	BPI	umls:C0009324	BeFree	Our study is the first one reporting a novel association between BPI gene mutation (Lys216Glu) and UC.	0.006091273	2011	BPI;LOC105372612	20	38318446	G	A
rs4510766	21297633	1811	SLC26A3	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.132106602	2011	NA	7	107852344	A	G
rs4537545	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	IL6R	1	154446403	C	T
rs4537545	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	IL6R	1	154446403	C	T
rs4537545	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	IL6R	1	154446403	C	T
rs4537545	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	IL6R	1	154446403	C	T
rs4537545	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	IL6R	1	154446403	C	T
rs4537545	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	IL6R	1	154446403	C	T
rs4537545	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	IL6R	1	154446403	C	T
rs4537545	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	IL6R	1	154446403	C	T
rs4537545	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	IL6R	1	154446403	C	T
rs4537545	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	IL6R	1	154446403	C	T
rs4537545	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	IL6R	1	154446403	C	T
rs4537545	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	IL6R	1	154446403	C	T
rs4537545	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	IL6R	1	154446403	C	T
rs4553808	20445568	1493	CTLA4	umls:C0009324	BeFree	CTLA4 gene -1661A/G and long 3' untranslated region (AT)n repeat polymorphisms are associated with UC in Central China.	0.031204679	2010	CTLA4	2	203866282	A	G
rs4598195	19122664	1738	DLD	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.004734064	2009	LOC105375444	7	107862996	A	C
rs4598195	20228799	1738	DLD	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.004734064	2010	LOC105375444	7	107862996	A	C
rs4598195	19122664	1811	SLC26A3	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.132106602	2009	LOC105375444	7	107862996	A	C
rs4598195	20228799	1811	SLC26A3	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.132106602	2010	LOC105375444	7	107862996	A	C
rs4598195	20228799	3912	LAMB1	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.12764398	2010	LOC105375444	7	107862996	A	C
rs4598195	19122664	3912	LAMB1	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12764398	2009	LOC105375444	7	107862996	A	C
rs4654925	20228798	23252	OTUD3	umls:C0009324	GWASCAT	Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).	0.129468128	2010	OTUD3	1	19901230	G	C,T
rs4654925	20228798	23252	OTUD3	umls:C0009324	GAD	[Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).]	0.129468128	2010	OTUD3	1	19901230	G	C,T
rs4663396	22457781	55054	ATG16L1	umls:C0009324	BeFree	Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC.	0.03283333	2012	ATG16L1	2	233283605	C	T
rs4676406	21297633	2859	GPR35	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002638474	2011	NA	2	240639691	G	T
rs4696480	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR2	4	153685974	T	A
rs4696480	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR2	4	153685974	T	A
rs4696480	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR2	4	153685974	T	A
rs4696480	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR2	4	153685974	T	A
rs4696480	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR2	4	153685974	T	A
rs4696480	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR2	4	153685974	T	A
rs4696480	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR2	4	153685974	T	A
rs4696480	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR2	4	153685974	T	A
rs4696480	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR2	4	153685974	T	A
rs4696480	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR2	4	153685974	T	A
rs4696480	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR2	4	153685974	T	A
rs4696480	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR2	4	153685974	T	A
rs4696480	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR2	4	153685974	T	A
rs4696480	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR2	4	153685974	T	A
rs4696480	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR2	4	153685974	T	A
rs4728142	22685416	22915	MMRN1	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	NA	7	128933913	G	A
rs4728142	22685416	6579	SLCO1A2	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	NA	7	128933913	G	A
rs4728142	22685416	3663	IRF5	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.121357209	2012	NA	7	128933913	G	A
rs4728142	21297633	375616	KCP	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	NA	7	128933913	G	A
rs4730273	19122664	1811	SLC26A3	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.132106602	2009	NA	7	107839074	C	A
rs4730276	19122664	1811	SLC26A3	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.132106602	2009	NA	7	107843992	G	A
rs4730276	19122664	3912	LAMB1	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12764398	2009	NA	7	107843992	G	A
rs4730276	19122664	1738	DLD	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.004734064	2009	NA	7	107843992	G	A
rs4781011	20228799	4261	CIITA	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002367032	2010	CIITA;LOC105371080	16	10881454	T	G
rs4819388	22592522	9844	ELMO1	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000271442	2012	ICOSLG	21	44227538	T	C
rs4819388	22592522	102723996	LOC102723996	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000542884	2012	ICOSLG	21	44227538	T	C
rs4819388	22592522	117289	TAGAP	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000271442	2012	ICOSLG	21	44227538	T	C
rs483905	23128233	84441	MAML2	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	MAML2	11	96290263	G	A
rs4848306	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	NA	2	112840530	G	A
rs4848306	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	NA	2	112840530	G	A
rs4848306	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	NA	2	112840530	G	A
rs4848306	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	NA	2	112840530	G	A
rs4848306	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	NA	2	112840530	G	A
rs4848306	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	NA	2	112840530	G	A
rs4848306	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	NA	2	112840530	G	A
rs4848306	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	NA	2	112840530	G	A
rs4848306	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	NA	2	112840530	G	A
rs4848306	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	NA	2	112840530	G	A
rs4848306	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	NA	2	112840530	G	A
rs4848306	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	NA	2	112840530	G	A
rs4848306	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	NA	2	112840530	G	A
rs4848306	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	NA	2	112840530	G	A
rs4848306	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	NA	2	112840530	G	A
rs4957048	20228799	11076	TPPP	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002367032	2010	NA	5	583327	G	A
rs4957048	20228799	6550	SLC9A3	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.005276948	2010	NA	5	583327	G	A
rs4957048	20228799	55722	CEP72	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.002367032	2010	NA	5	583327	G	A
rs4958847	19491842	55054	ATG16L1	umls:C0009324	BeFree	In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.	0.03283333	2009	IRGM	5	150860025	G	A
rs4958847	19491842	345611	IRGM	umls:C0009324	BeFree	In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.	0.123995683	2009	IRGM	5	150860025	G	A
rs4958847	19098858	8792	TNFRSF11A	umls:C0009324	BeFree	Allele and genotype frequencies of rs1000113 and rs4958847 were determined in 823 CD (265 younger than 19 years at diagnosis), 353 ulcerative colitis (UC) (130 younger than 19 years at diagnosis), and 578 controls.	0.000271442	2009	IRGM	5	150860025	G	A
rs4986790	17850411	7099	TLR4	umls:C0009324	BeFree	The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.	0.034352361	2007	TLR4	9	117713024	A	G
rs4986790	20093834	7099	TLR4	umls:C0009324	BeFree	The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis.	0.034352361	2010	TLR4	9	117713024	A	G
rs4986790	15194649	7099	TLR4	umls:C0009324	BeFree	We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.	0.034352361	2004	TLR4	9	117713024	A	G
rs4986790	23470644	7099	TLR4	umls:C0009324	BeFree	TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis.	0.034352361	2014	TLR4	9	117713024	A	G
rs4986790	22918682	7099	TLR4	umls:C0009324	BeFree	The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.	0.034352361	2013	TLR4	9	117713024	A	G
rs4986790	23239925	7099	TLR4	umls:C0009324	BeFree	Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.	0.034352361	2012	TLR4	9	117713024	A	G
rs4986790	18680223	7099	TLR4	umls:C0009324	BeFree	To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.	0.034352361	2008	TLR4	9	117713024	A	G
rs4986791	17850411	7099	TLR4	umls:C0009324	BeFree	The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.	0.034352361	2007	TLR4	9	117713324	C	T
rs4986791	20093834	7099	TLR4	umls:C0009324	BeFree	The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis.	0.034352361	2010	TLR4	9	117713324	C	T
rs4986791	23239925	7099	TLR4	umls:C0009324	BeFree	Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.	0.034352361	2012	TLR4	9	117713324	C	T
rs4986791	22918682	7099	TLR4	umls:C0009324	BeFree	The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.	0.034352361	2013	TLR4	9	117713324	C	T
rs4986791	18680223	7099	TLR4	umls:C0009324	BeFree	To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.	0.034352361	2008	TLR4	9	117713324	C	T
rs5030728	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	TLR4	9	117712004	G	A
rs5030728	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	TLR4	9	117712004	G	A
rs5030728	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	TLR4	9	117712004	G	A
rs5030728	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	TLR4	9	117712004	G	A
rs5030728	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	TLR4	9	117712004	G	A
rs5030728	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	TLR4	9	117712004	G	A
rs5030728	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	TLR4	9	117712004	G	A
rs5030728	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	TLR4	9	117712004	G	A
rs5030728	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	TLR4	9	117712004	G	A
rs5030728	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	TLR4	9	117712004	G	A
rs5030728	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	TLR4	9	117712004	G	A
rs5030728	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	TLR4	9	117712004	G	A
rs5030728	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	TLR4	9	117712004	G	A
rs5030728	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	TLR4	9	117712004	G	A
rs5030728	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	TLR4	9	117712004	G	A
rs5743708	19303021	7033	TFF3	umls:C0009324	BeFree	The relevance of the observed functional effect of TLR2 in regulating GC is confirmed by the finding that the UC-associated TLR2-R753Q variant is functionally deficient in the ability to induce TFF3 synthesis, thus leading to impaired wound healing.	0.000814326	2009	TLR2	4	153705165	G	A
rs5743708	19303021	7097	TLR2	umls:C0009324	BeFree	The relevance of the observed functional effect of TLR2 in regulating GC is confirmed by the finding that the UC-associated TLR2-R753Q variant is functionally deficient in the ability to induce TFF3 synthesis, thus leading to impaired wound healing.	0.011996981	2009	TLR2	4	153705165	G	A
rs5743810	16374251	10333	TLR6	umls:C0009324	BeFree	There was a negative association between TLR6 S249P and ulcerative colitis with proctitis only (P = .026, OR [95% CI] 0.223 [0.096-0.705]).	0.002638474	2006	TLR6	4	38828729	A	G
rs5743836	19455129	9231	DLG5	umls:C0009324	BeFree	The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.	0.007177041	2009	TLR9	3	52226766	A	G
rs5743836	19455129	50941	IBD5	umls:C0009324	BeFree	The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.	0.019912403	2009	TLR9	3	52226766	A	G
rs5771069	21297633	400935	IL17REL	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.245005506	2011	IL17REL	22	49997051	A	G
rs5771069	20228798	400935	IL17REL	umls:C0009324	GAD	[Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).]	0.245005506	2010	IL17REL	22	49997051	A	G
rs5771069	21297633	400935	IL17REL	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.245005506	2011	IL17REL	22	49997051	A	G
rs5771069	20228798	400935	IL17REL	umls:C0009324	GWASCAT	Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).	0.245005506	2010	IL17REL	22	49997051	A	G
rs6017342	19915572	3172	HNF4A	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.126362715	2009	NA	20	44436388	A	C
rs6017342	21297633	3172	HNF4A	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.126362715	2011	NA	20	44436388	A	C
rs6088765	23128233	10544	PROCR	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	PROCR	20	35211477	T	G
rs6426833	19915572	54546	RNF186	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.12973957	2009	NA	1	19845367	G	A
rs6426833	19915572	23252	OTUD3	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.129468128	2009	NA	1	19845367	G	A
rs6426833	19122664	54546	RNF186	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.12973957	2009	NA	1	19845367	G	A
rs6426833	20228799	30814	PLA2G2E	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.007101096	2010	NA	1	19845367	G	A
rs6426833	21297633	54546	RNF186	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.12973957	2011	NA	1	19845367	G	A
rs6426833	19122664	23252	OTUD3	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.129468128	2009	NA	1	19845367	G	A
rs6426833	20228799	23252	OTUD3	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.129468128	2010	NA	1	19845367	G	A
rs6426833	19915572	30814	PLA2G2E	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.007101096	2009	NA	1	19845367	G	A
rs6426833	20228799	54546	RNF186	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.12973957	2010	NA	1	19845367	G	A
rs6426833	19122664	30814	PLA2G2E	umls:C0009324	GAD	[Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.]	0.007101096	2009	NA	1	19845367	G	A
rs6451493	21297633	1601	DAB2	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	NA	5	40410833	G	T
rs6532197	22685416	6579	SLCO1A2	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	NA	4	89876150	A	G
rs6532197	22685416	3663	IRF5	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.121357209	2012	NA	4	89876150	A	G
rs6532197	22685416	22915	MMRN1	umls:C0009324	BeFree	We identified novel cisSNP/transcript associations for human disease-associated variants, including progressive supranuclear palsy SLCO1A2/rs11568563, Parkinson's disease (PD) MMRN1/rs6532197, Paget's disease OPTN/rs1561570; and we confirmed others, including PD MAPT/rs242557, systemic lupus erythematosus and ulcerative colitis IRF5/rs4728142, and type 1 diabetes mellitus RPS26/rs1701704.	0.000271442	2012	NA	4	89876150	A	G
rs6569648	24911414	60498	IGAN1	umls:C0009324	BeFree	These four variants are implicated in complex phenotypes such as ulcerative colitis and AIDS progression disease (rs10491434), Celiac disease (rs2762051), Crohn's disease, IgA nephropathy and early-onset inflammatory bowel disease (rs713875) and height (rs6569648).	0.000271442	2014	L3MBTL3	6	130027974	C	T
rs6584283	19915572	2805	GOT1	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.007101096	2009	LINC01475	10	99530544	T	C
rs6584283	19915572	101927324	LINC01475	umls:C0009324	GWASCAT	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	0.12	2009	LINC01475	10	99530544	T	C
rs6584283	21297633	101927324	LINC01475	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.12	2011	LINC01475	10	99530544	T	C
rs6584283	21297633	2805	GOT1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.007101096	2011	LINC01475	10	99530544	T	C
rs6584283	20228798	2805	GOT1	umls:C0009324	GAD	[Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).]	0.007101096	2010	LINC01475	10	99530544	T	C
rs6596473	24284447	27034	ACAD8	umls:C0009324	BeFree	Genomic DNA samples from patients with CD (n = 162) and UC (n = 149) from the Manitoba IBD Cohort Study and ethnically matched controls (n = 142) were genotyped for 3 SLC23A1 polymorphisms (rs6596473, rs33972313, and rs10063949) by using TaqMan assays.	0.010043349	2014	SLC23A1	5	139374887	G	C
rs6596473	24284447	9963	SLC23A1	umls:C0009324	BeFree	A strong linkage disequilibrium (LD) was observed across the SLC23A1 region (variation rs6596473 with rs10063949) for CD and UC (D' = 0.94 and 0.96, respectively).	0.000271442	2014	SLC23A1	5	139374887	G	C
rs678170	21297633	120400	NXPE1	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.122367032	2011	NXPE1	11	114561234	A	G
rs678170	21297633	120400	NXPE1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.122367032	2011	NXPE1	11	114561234	A	G
rs6785049	21245992	8856	NR1I2	umls:C0009324	BeFree	PXR A7635G (rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease (OR: 1.34, 95% CI: 1.03-1.75 and OR: 2.49, 95% CI: 1.24-5.03, respectively).	0.010258709	2011	NR1I2	3	119814886	G	A
rs6871626	21297633	3593	IL12B	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.134092571	2011	NA	5	159399784	C	A
rs6887695	25761185	3593	IL12B	umls:C0009324	BeFree	Our genetic association study revealed that the polymorphisms of IL12B rs6887695 were associated with both CD and ulcerative colitis (UC) susceptibility in Chinese population, but did not affect the serum IL12p40 level in either CD patients or UC patients.	0.134092571	2015	NA	5	159395637	G	C
rs6887695	22479607	3593	IL12B	umls:C0009324	BeFree	Our analysis revealed an association of the IL12B SNP rs6887695 with susceptibility to IBD (p = 0.035; OR 1.15 [95% CI 1.01-1.31] including a trend for rs6887695 for association with CD (OR 1.41; [0.99-1.31], p = 0.066) and UC (OR 1.18 [0.97-1.43], p = 0.092).	0.134092571	2012	NA	5	159395637	G	C
rs6908425	19174780	54901	CDKAL1	umls:C0009324	GAD	[Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.]	0.005005506	2009	CDKAL1	6	20728500	T	C
rs6920220	21297633	167826	OLIG3	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	NA	6	137685367	G	A
rs6927022	23128233	3117	HLA-DQA1	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.124734064	2012	HLA-DQA1	6	32644620	A	G
rs6927172	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	NA	6	137681038	C	G
rs6927172	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	NA	6	137681038	C	G
rs6927172	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	NA	6	137681038	C	G
rs6927172	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	NA	6	137681038	C	G
rs6927172	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	NA	6	137681038	C	G
rs6927172	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	NA	6	137681038	C	G
rs6927172	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	NA	6	137681038	C	G
rs6927172	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	NA	6	137681038	C	G
rs6927172	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	NA	6	137681038	C	G
rs6927172	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	NA	6	137681038	C	G
rs6927172	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	NA	6	137681038	C	G
rs6927172	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	NA	6	137681038	C	G
rs6927172	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	NA	6	137681038	C	G
rs6927172	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	NA	6	137681038	C	G
rs6927172	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	NA	6	137681038	C	G
rs696	24971461	3586	IL10	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.294635894	2014	NFKBIA	14	35401887	C	T
rs696	24971461	7097	TLR2	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.011996981	2014	NFKBIA	14	35401887	C	T
rs696	24971461	7124	TNF	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.18707607	2014	NFKBIA	14	35401887	C	T
rs696	24971461	149233	IL23R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.326936272	2014	NFKBIA	14	35401887	C	T
rs696	24971461	7132	TNFRSF1A	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.007915422	2014	NFKBIA	14	35401887	C	T
rs696	24971461	4790	NFKB1	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.1312586	2014	NFKBIA	14	35401887	C	T
rs696	24971461	7099	TLR4	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.034352361	2014	NFKBIA	14	35401887	C	T
rs696	24971461	23643	LY96	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000542884	2014	NFKBIA	14	35401887	C	T
rs696	24971461	5468	PPARG	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.012897183	2014	NFKBIA	14	35401887	C	T
rs696	24971461	26191	PTPN22	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.009001189	2014	NFKBIA	14	35401887	C	T
rs696	24971461	54106	TLR9	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.008729747	2014	NFKBIA	14	35401887	C	T
rs696	24971461	3570	IL6R	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.000271442	2014	NFKBIA	14	35401887	C	T
rs696	24971461	4792	NFKBIA	umls:C0009324	BeFree	The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.	0.001085767	2014	NFKBIA	14	35401887	C	T
rs6974491	22592522	7332	UBE2L3	umls:C0009324	BeFree	In the subphenotype analysis, rs6974491-ELMO1 (P=0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P=5.44 × 10(-5), OR: 2.59) associated with pediatric UC and CD, respectively.	0.000542884	2012	ELMO1	7	37334906	G	A
rs6974491	22592522	102723996	LOC102723996	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000542884	2012	ELMO1	7	37334906	G	A
rs6974491	22592522	9844	ELMO1	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000271442	2012	ELMO1	7	37334906	G	A
rs6974491	22592522	117289	TAGAP	umls:C0009324	BeFree	In the subphenotype meta-analysis, rs1738074-TAGAP (P=7.40 × 10(-5), OR: 0.61), rs6974491-ELMO1 (P=0.00052, OR: 1.73) and rs4819388-ICOSLG (P=0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively.	0.000271442	2012	ELMO1	7	37334906	G	A
rs713875	24911414	60498	IGAN1	umls:C0009324	BeFree	These four variants are implicated in complex phenotypes such as ulcerative colitis and AIDS progression disease (rs10491434), Celiac disease (rs2762051), Crohn's disease, IgA nephropathy and early-onset inflammatory bowel disease (rs713875) and height (rs6569648).	0.000271442	2014	HORMAD2;LOC105372988	22	30196498	C	G
rs7210086	23128233	201266	SLC39A11	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	SLC39A11	17	72645559	A	C
rs7222094	24776844	3458	IFNG	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011530042	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	3605	IL17A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007795869	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	23643	LY96	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000542884	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	3557	IL1RN	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.033452159	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	54106	TLR9	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.008729747	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	9020	MAP3K14	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.000271442	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	7132	TNFRSF1A	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.007915422	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	4790	NFKB1	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.1312586	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	3553	IL1B	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.144069907	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	4695	NDUFA2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.003528744	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	7128	TNFAIP3	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.002909916	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	7099	TLR4	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.034352361	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	7124	TNF	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.18707607	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	3569	IL6	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.009510397	2014	MAP3K14	17	45290287	T	C
rs7222094	24776844	7097	TLR2	umls:C0009324	BeFree	Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).	0.011996981	2014	MAP3K14	17	45290287	T	C
rs7234029	22457781	55054	ATG16L1	umls:C0009324	BeFree	Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC.	0.03283333	2012	PTPN2	18	12877061	A	G
rs734999	21297633	100996583	LOC100996583	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.12	2011	LOC100996583	1	2581777	C	T
rs734999	21297633	8764	TNFRSF14	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.002367032	2011	LOC100996583	1	2581777	C	T
rs744166	22269120	9034	CCRL2	umls:C0009324	BeFree	Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.	0.001085767	2012	STAT3	17	42362183	A	G
rs744166	25286337	6774	STAT3	umls:C0009324	BeFree	Associations between STAT3 rs744166 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.	0.135254284	2014	STAT3	17	42362183	A	G
rs744166	22065112	6774	STAT3	umls:C0009324	BeFree	Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.	0.135254284	2012	STAT3	17	42362183	A	G
rs744166	22065112	3717	JAK2	umls:C0009324	BeFree	Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.	0.131368221	2012	STAT3	17	42362183	A	G
rs74825699	21245992	4790	NFKB1	umls:C0009324	BeFree	Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.	0.1312586	2011	NR1I2	3	119783118	G	A
rs74825699	21245992	8856	NR1I2	umls:C0009324	BeFree	PXR A7635G (rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease (OR: 1.34, 95% CI: 1.03-1.75 and OR: 2.49, 95% CI: 1.24-5.03, respectively).	0.010258709	2011	NR1I2	3	119783118	G	A
rs7517847	22735800	149233	IL23R	umls:C0009324	BeFree	IL-23 receptor gene rs7517847 and rs1004819 SNPs in ulcerative colitis.	0.326936272	2014	IL23R	1	67215986	T	G
rs7517847	18383521	149233	IL23R	umls:C0009324	BeFree	The data show an association of both IL23R SNPs with overall IBD (statistically stronger, rs7517847; odds ratio [OR] = 0.79, 95% confidence interval [CI]: 0.67-0.94, minor allele frequencies: 0.355 in IBD patients versus 0.410 in controls; P = 0.005), somewhat stronger in Crohn's disease (OR = 0.74, 95% CI: 0.61-0.91) than in ulcerative colitis (OR = 0.84, 95% CI: 0.69-1.03).	0.326936272	2008	IL23R	1	67215986	T	G
rs7524102	21297633	54361	WNT4	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.004734064	2011	NA	1	22371954	A	G
rs7524102	19915572	54361	WNT4	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.004734064	2009	NA	1	22371954	A	G
rs7528684	17389014	64127	NOD2	umls:C0009324	BeFree	Our aim was to study the role of two promoter SNPs of the FCRL3 gene (-169A>G, rs7528684 and -110C>T, rs11264799) in patients with IBD and their interaction with HLA-DRB1 and CARD15 in patients with UC and CD, respectively.	0.233979892	2007	FCRL3	1	157701026	A	G
rs7530511	24611330	149233	IL23R	umls:C0009324	BeFree	The aim of this study was to determine whether the specific rs11209026 and rs7530511 single-nucleotide polymorphisms in the Interleukin-23 receptor gene are associated with Crohn's disease and ulcerative colitis in a Croatian patient population.	0.326936272	2014	IL23R	1	67219704	T	C
rs7530511	19294505	149233	IL23R	umls:C0009324	BeFree	The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.	0.326936272	2010	IL23R	1	67219704	T	C
rs7530511	25159710	149233	IL23R	umls:C0009324	BeFree	We found that IL23R (L310P) variant conferred a protective effect for crohn's disease (CD) but not ulcerative colitis (UC) patients.	0.326936272	2014	IL23R	1	67219704	T	C
rs7554511	21297633	55765	C1orf106	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.124734064	2011	C1orf106	1	200908434	C	A
rs7554511	19915572	55765	C1orf106	umls:C0009324	GWASCAT	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	0.124734064	2009	C1orf106	1	200908434	C	A
rs7554511	21297633	55765	C1orf106	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.124734064	2011	C1orf106	1	200908434	C	A
rs7554511	19915572	55765	C1orf106	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.124734064	2009	C1orf106	1	200908434	C	A
rs7554511	19915572	23046	KIF21B	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.122367032	2009	C1orf106	1	200908434	C	A
rs7568275	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191101726	G	C
rs7574865	18759272	6775	STAT4	umls:C0009324	BeFree	The association of STAT4 polymorphism rs7574865 with RA was validated in patients of Spanish origin (for T versus G, P = 1.2 x 10(-6), odds ratio [OR] 1.59, 95% confidence interval [95% CI] 1.31-1.92), and the association was described for the first time in both clinical forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis (for T versus G, P = 0.006, OR 1.29, 95% CI 1.07-1.55), and in type 1 diabetes mellitus (for T versus G, P = 0.008, OR 1.36, 95% CI 1.07-1.71).	0.006362715	2008	STAT4	2	191099907	T	G
rs7574865	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191099907	T	G
rs7582694	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191105394	C	G
rs7608910	21297633	150962	PUS10	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.127101096	2011	PUS10	2	60977721	A	G
rs7608910	21297633	150962	PUS10	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.127101096	2011	PUS10	2	60977721	A	G
rs763780	23652560	112744	IL17F	umls:C0009324	BeFree	The IL17F (rs763780, 7488T/C) variant was associated with an increased risk for the development of CD, and affected some clinical features of UC and CD.	0.003724241	2013	IL17F;LOC105375088	6	52236941	T	C
rs763780	18088064	149233	IL23R	umls:C0009324	BeFree	Given the association of IL23R with inflammatory bowel disease (IBD), we characterized the role of IL-17F in IBD including its intestinal gene expression and the effect of the IL17F p.His161Arg polymorphism on disease susceptibility and phenotype of Crohn's disease (CD) and ulcerative colitis (UC).	0.326936272	2008	IL17F;LOC105375088	6	52236941	T	C
rs7744	24189845	4615	MYD88	umls:C0009324	BeFree	The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis.	0.000814326	2013	MYD88	3	38142530	A	G
rs7809799	20228798	57154	SMURF1	umls:C0009324	GAD	[Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).]	0.002367032	2010	NA	7	99162881	G	A
rs798502	21297633	2768	GNA12	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.242638474	2011	GNA12;AMZ1	7	2750246	A	C
rs798502	23128233	2768	GNA12	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.242638474	2012	GNA12;AMZ1	7	2750246	A	C
rs798502	21297633	2768	GNA12	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.242638474	2011	GNA12;AMZ1	7	2750246	A	C
rs8067378	20228799	124626	ZPBP2	umls:C0009324	GAD	[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]	0.004734064	2010	NA	17	39895095	A	G
rs8179673	20454450	6775	STAT4	umls:C0009324	BeFree	Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238).	0.006362715	2010	STAT4	2	191104615	C	T
rs886774	19915572	3912	LAMB1	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.12764398	2009	NA	7	107854989	G	A
rs886774	19915572	1811	SLC26A3	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.132106602	2009	NA	7	107854989	G	A
rs907611	21297633	4046	LSP1	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.242367032	2011	LSP1	11	1852842	G	A
rs907611	21297633	4046	LSP1	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.242367032	2011	LSP1	11	1852842	G	A
rs917997	18439550	64127	NOD2	umls:C0009324	BeFree	Joint analysis of 1851 IBD patients (1062 CD, 789 UC) and 1936 controls demonstrated strong association to the IL18RAP rs917997 SNP for both CD and UC (p(IBD) 1.9 x 10(-8); OR 1.35).	0.233979892	2008	NA	2	102454108	T	C
rs925847	20176035	6775	STAT4	umls:C0009324	BeFree	SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR=0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility.	0.006362715	2010	STAT4;LOC105373805	2	191032814	C	T
rs9263739	19915573	54535	CCHCR1	umls:C0009324	GWASCAT	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.	0.122367032	2009	CCHCR1	6	31143579	C	T
rs9263739	19915573	54535	CCHCR1	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.122367032	2009	CCHCR1	6	31143579	C	T
rs9268480	19915573	56244	BTNL2	umls:C0009324	GAD	[A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.]	0.017469426	2009	BTNL2;LOC101929163	6	32396067	C	T
rs9268877	18836448	3122	HLA-DRA	umls:C0009324	GAD	[Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.]	0.012106602	2008	NA	6	32463370	A	G
rs9268877	18836448	56244	BTNL2	umls:C0009324	GAD	[Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.]	0.017469426	2008	NA	6	32463370	A	G
rs9268923	20228798	3122	HLA-DRA	umls:C0009324	GAD	[Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).]	0.012106602	2010	NA	6	32465058	C	T
rs941823	21297633	646982	LINC00598	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.12	2011	LINC00598	13	40439840	T	C
rs941823	21297633	57511	COG6	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.004734064	2011	LINC00598	13	40439840	T	C
rs943072	21297633	7422	VEGFA	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.003452799	2011	NA	6	43828231	G	T
rs9548988	19915572	57511	COG6	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.004734064	2009	NA	13	39931373	C	T
rs9822268	21297633	327	APEH	umls:C0009324	GWASCAT	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	0.122367032	2011	APEH	3	49682296	G	A
rs9822268	21297633	327	APEH	umls:C0009324	GAD	[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]	0.122367032	2011	APEH	3	49682296	G	A
rs9847710	23128233	51460	SFMBT1	umls:C0009324	GWASCAT	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	0.12	2012	SFMBT1;LOC105377135	3	53028645	T	C
rs9858542	19915572	8927	BSN	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.122638474	2009	BSN	3	49664550	G	A
rs9858542	19915572	8927	BSN	umls:C0009324	GWASCAT	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	0.122638474	2009	BSN	3	49664550	G	A
rs9858542	19915572	4485	MST1	umls:C0009324	GAD	[Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.]	0.254092571	2009	BSN	3	49664550	G	A
rs9858542	20024904	4485	MST1	umls:C0009324	BeFree	BSN and MST1 were significantly associated with either CD (P(rs9858542) 2.5 x 10(-7); P(rs3197999) 3.9 x 10(-7)), and UC (P(rs9858542) = 3.1 x 10(-4); P(rs3197999) = 8 x 10(-4)).	0.254092571	2010	BSN	3	49664550	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:212)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	2501338	rs10797432	C	T	rs10797432	23128233	3.00E-12	NA	1.08	[1.04-1.12]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10797432-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	2513216	rs734999	C	T	rs734999	21297633	3.00E-09	NA	1.05	[1.01-1.09]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs734999-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	8021973	rs35675666	G	T	rs35675666	21297633	5.00E-09	NA	1.08	[1.02-1.15]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs35675666-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	20140036	rs1317209	G	A	rs1317209	20228799	2.00E-10	NA	1.17	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1317209-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
1	20142866	rs3806308	C	T	rs3806308	19122664	7.00E-09	NA	1.28	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
1	20171860	rs6426833	G	A	rs6426833	19122664	5.00E-13	NA	1.37	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6426833-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	20171860	rs6426833	G	A	rs6426833	19915572	2.00E-11	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	20171860	rs6426833	G	A	rs6426833	20228799	2.00E-21	NA	1.3	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6426833-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	20171860	rs6426833	G	A	rs6426833	21297633	4.00E-35	NA	1.3	[1.25-1.35]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6426833-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	20171860	rs6426833	G	A	rs6426833	23128233	2.00E-68	NA	1.27	[1.22-1.31]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6426833-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	20171860	rs6426833	G	A	rs6426833	23511034	7.22E-08	NA	1.53	[1.31-1.79]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6426833-A	Research Support, Non-U.S. Gov't	Comparative Study	G
1	20200990	rs4654903	A	G	rs4654903	23511034	7.00E-09	NA	1.56	[1.35-1.82]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
1	20227723	rs4654925	G	C,T	rs4654925	20228798	9.00E-22	NA	1.41	[1.30-1.54]	1,043 German cases; 1,703 German controls	German(2746)	ALL(2746)	EUR(2746)	ALL(2746)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4654925-G	Research Support, Non-U.S. Gov't	G	OTUD3
1	22698447	rs7524102	A	G	rs7524102	19915572	3.00E-07	NA	1.1	[1.00-1.21]	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7524102-A	Research Support, Non-U.S. Gov't	G	NA
1	22698447	rs7524102	A	G	rs7524102	21297633	2.00E-13	NA	1.1	[1.05-1.16]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7524102-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	22702231	rs12568930	T	C	rs12568930	19915572	1.40E-07	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
1	67694202	rs2201841	A	G	rs2201841	20228799	1.00E-13	NA	1.27	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2201841-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
1	67705958	rs11209026	G	A	rs11209026	19122664	1.00E-08	NA	1.79	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	67705958	rs11209026	G	A	rs11209026	19915572	3.00E-10	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	IL23R
1	67705958	rs11209026	G	A	rs11209026	21297633	5.00E-28	NA	1.74	[1.57-1.92]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11209026-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	67725120	rs10889677	C	A	rs10889677	19122664	1.00E-08	NA	1.29	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10889677-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	161462728	rs4657039	A	G	rs4657039	19915573	2.20E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	A	NA
1	161463331	rs7511868	G	A	rs7511868	19915573	5.42E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	A	NA
1	161463814	rs6696854	T	C	rs6696854	19915573	3.65E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T,C	NA
1	161464412	rs6684851	C	T	rs6684851	19915573	3.67E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
1	161470505	rs12139150	G	C	rs12139150	19915573	2.81E-06	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	161472158	rs10800309	A	G	rs10800309	19915573	2.22E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	161472158	rs10800309	A	G	rs10800309	20228799	3.00E-09	NA	1.2	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10800309-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	161478810	rs6671847	G	A	rs6671847	19915573	8.50E-09	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	FCGR2A
1	161479745	rs1801274	A	G	rs1801274	19915573	2.00E-12	NA	1.59	[1.39-1.82]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1801274-G	Research Support, Non-U.S. Gov't	T	FCGR2A
1	161479745	rs1801274	A	G	rs1801274	21297633	2.00E-20	NA	1.21	[1.16-1.26]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1801274-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	161479745	rs1801274	A	G	rs1801274	23511034	2.12E-04	NA	1.33	[1.14-1.54]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1801274-A	Research Support, Non-U.S. Gov't	Comparative Study	T
1	198656407	rs2359952	A	G	rs2359952	24837172	4.00E-07	NA	1.31	[1.13-1.51]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2359952-A	Research Support, Non-U.S. Gov't	G	PTPRC
1	200101920	rs2816958	A	G	rs2816958	23128233	2.00E-17	NA	1.23	[1.16-1.30]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2816958-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	200877562	rs7554511	C	A	rs7554511	19915572	1.00E-06	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	C1orf106
1	200877562	rs7554511	C	A	rs7554511	21297633	2.00E-13	NA	1.19	[1.14-1.25]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7554511-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	200935866	rs11584383	T	C	rs11584383	20228799	2.00E-07	NA	1.27	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11584383-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
1	206939904	rs3024505	G	A	rs3024505	18836448	1.00E-12	NA	1.46	[1.31-1.62]	1,167 cases; 777 controls	NOPOP(1944)	ALL(1944)	NOPOP(1944)	ALL(1944)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3024505-T	Research Support, Non-U.S. Gov't	C	NA
1	206939904	rs3024505	G	A	rs3024505	20228799	1.00E-08	NA	1.23	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3024505-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	206939904	rs3024505	G	A	rs3024505	21297633	6.00E-17	NA	1.25	[1.19-1.32]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3024505-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	206943968	rs3024493	C	A	rs3024493	19915572	8.00E-08	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	IL10
1	206943968	rs3024493	C	A	rs3024493	20228798	1.00E-12	NA	1.35	[1.22-1.50]	1,043 German cases; 1,703 German controls	German(2746)	ALL(2746)	EUR(2746)	ALL(2746)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3024493-T	Research Support, Non-U.S. Gov't	G	IL10
1	206959527	rs17351243	G	A	rs17351243	19915573	8.42E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	206961628	rs12075255	A	G	rs12075255	19915573	1.87E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	206962416	rs885334	C	T	rs885334	19915573	1.98E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	206968893	rs11583394	C	T	rs11583394	19915573	5.60E-06	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
1	216789443	rs6673588	T	G	rs6673588	19915573	3.83E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	ESRRG
2	15843840	rs1862101	T	C	rs1862101	19915573	8.11E-06	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	A	NA
2	15856372	rs6746441	A	G	rs6746441	19915573	2.72E-06	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
2	15862330	rs7591368	C	A	rs7591368	19915573	6.07E-07	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
2	61186829	rs13003464	A	G	rs13003464	20228799	7.00E-09	NA	1.13	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs13003464-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	61204856	rs7608910	A	G	rs7608910	21297633	2.00E-14	NA	1.19	[1.14-1.24]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7608910-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	80915734	rs17019600	C	A	rs17019600	19915572	5.10E-05	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
2	102663628	rs2310173	T	G	rs2310173	21297633	3.00E-12	NA	1.09	[1.05-1.14]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2310173-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	102957716	rs1420101	C	T	rs1420101	24837172	6.00E-04	NA	1.2	[1.04-1.39]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1420101-G	Research Support, Non-U.S. Gov't	A	IL1RL1
2	198265526	rs788018	A	G	rs788018	24837172	7.00E-04	NA	1.22	[1.04-1.43]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs788018-G	Research Support, Non-U.S. Gov't	G	SF3B1
2	198369370	rs6434930	T	C	rs6434930	24837172	3.00E-04	NA	1.22	[1.05-1.43]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6434930-G	Research Support, Non-U.S. Gov't	C	HSPE1-MOB4
2	198403697	rs3792159	C	T	rs3792159	24837172	1.00E-04	NA	1.23	[1.06-1.44]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3792159-A	Research Support, Non-U.S. Gov't	A	MOB4
2	198881668	rs1016883	G	A	rs1016883	23128233	3.00E-08	NA	1.1	[1.05-1.15]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1016883-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	199523122	rs17229285	C	T	rs17229285	23128233	2.00E-13	NA	1.12	[1.08-1.16]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs17229285-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	200290359	rs1992950	A	G	rs1992950	20228799	5.00E-06	NA	1.1	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1992950-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	219010146	rs11676348	C	T	rs11676348	21297633	1.00E-10	NA	1.07	[1.03-1.11]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11676348-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	241579108	rs4676406	G	T	rs4676406	21297633	8.00E-11	NA	1.14	[1.09-1.18]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4676406-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	241597150	rs6437358	G	C	rs6437358	19915572	5.90E-07	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
3	49701983	rs9858542	G	A	rs9858542	19915572	7.00E-09	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	BSN
3	49719729	rs9822268	G	A	rs9822268	21297633	2.00E-17	NA	1.21	[1.16-1.26]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9822268-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	49721532	rs3197999	G	A	rs3197999	20228799	4.00E-09	NA	1.2	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3197999-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
3	53062661	rs9847710	T	C	rs9847710	23128233	1.00E-08	NA	1.06	[1.03-1.10]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9847710-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	175806373	rs9875122	C	T	rs9875122	19915573	9.58E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
4	103511114	rs3774959	G	A	rs3774959	23128233	4.00E-12	NA	1.12	[1.08-1.16]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3774959-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	123329362	rs17388568	G	A	rs17388568	21297633	9.00E-07	NA	1.12	[1.07-1.17]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs17388568-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	180284814	rs6811556	T	C	rs6811556	20848476	9.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	T
5	583442	rs4957048	G	A	rs4957048	20228799	1.00E-09	NA	1.3	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4957048-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	594083	rs11739663	T	C	rs11739663	21297633	3.00E-08	NA	1.15	[1.09-1.21]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11739663-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	594083	rs11739663	T	C	rs11739663	23128233	2.00E-08	NA	1.07	[1.03-1.12]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11739663-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	10752315	rs267939	C	T	rs267939	21297633	6.00E-12	NA	1.1	[1.06-1.15]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs267939-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	35876274	rs3194051	A	G	rs3194051	21297633	4.00E-08	NA	1.07	[1.02-1.12]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3194051-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	40410935	rs6451493	G	T	rs6451493	21297633	3.00E-09	NA	1.08	[1.04-1.12]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6451493-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	107834247	rs4571457	C	T	rs4571457	20848476	7.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	T
5	134443606	rs254560	G	A	rs254560	21297633	1.00E-09	NA	1.07	[1.03-1.12]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs254560-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	134443606	rs254560	G	A	rs254560	23128233	3.00E-09	NA	1.06	[1.02-1.09]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs254560-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	158826792	rs6871626	C	A	rs6871626	21297633	1.00E-21	NA	1.17	[1.12-1.22]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6871626-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	29934163	rs6935053	A	C	rs6935053	23511034	2.00E-06	Conditioned on rs9271366	NA	NA	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
6	30799399	rs9501030	T	A	rs9501030	20848476	4.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	A
6	31111356	rs9263739	C	T	rs9263739	19915573	4.00E-67	NA	2.73	[2.43-3.07]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9263739-T	Research Support, Non-U.S. Gov't	C	CCHCR1
6	31448862	rs3749946	C	A	rs3749946	24837172	2.00E-15	NA	1.97	[1.66-2.33]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs3749946-A	Research Support, Non-U.S. Gov't	NA	NA
6	31603591	rs2261033	A	G	rs2261033	24837172	1.81E-08	NA	1.34	[1.21-1.48]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2261033-G	Research Support, Non-U.S. Gov't	T	PRRC2A
6	31726688	rs707939	C	A	rs707939	24837172	7.02E-10	NA	1.51	[1.32-1.72]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs707939-A	Research Support, Non-U.S. Gov't	G	MSH5
6	31777946	rs2075800	C	T	rs2075800	24837172	2.44E-10	NA	1.41	[1.27-1.56]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2075800-A	Research Support, Non-U.S. Gov't	G	HSPA1L
6	31843924	rs2736428	C	T	rs2736428	24837172	4.86E-11	NA	1.43	[1.28-1.59]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2736428-A	Research Support, Non-U.S. Gov't	G	SLC44A4
6	31917540	rs4151657	T	C	rs4151657	24837172	5.00E-14	NA	1.54	[1.38-1.73]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4151657-G	Research Support, Non-U.S. Gov't	T	CFB
6	32079567	rs17207986	T	C	rs17207986	20848476	1.00E-16	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	C,T
6	32205045	rs549182	G	A	rs549182	24837172	8.00E-10	NA	1.59	[1.37-1.85]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs549182-A	Research Support, Non-U.S. Gov't	G	NA
6	32363844	rs9268480	C	T	rs9268480	19915573	3.00E-06	NA	1.82	[1.43-2.33]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9268480-G	Research Support, Non-U.S. Gov't	C	BTNL2
6	32429643	rs9268853	T	C	rs9268853	21297633	1.00E-55	NA	1.4	[1.34-1.47]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9268853-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32429643	rs9268853	T	C	rs9268853	23511034	3.00E-06	NA	1.37	[1.20-1.56]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9268853-T	Research Support, Non-U.S. Gov't	Comparative Study	T
6	32431147	rs9268877	A	G	rs9268877	18836448	6.00E-18	NA	1.45	[1.33-1.58]	1,167 cases; 777 controls	NOPOP(1944)	ALL(1944)	NOPOP(1944)	ALL(1944)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9268877-T	Research Support, Non-U.S. Gov't	G	NA
6	32431147	rs9268877	A	G	rs9268877	19915572	4.00E-23	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
6	32432835	rs9268923	C	T	rs9268923	20228798	4.00E-15	NA	1.45	[1.33-1.59]	1,043 German cases; 1,703 German controls	German(2746)	ALL(2746)	EUR(2746)	ALL(2746)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9268923-C	Research Support, Non-U.S. Gov't	C	NA
6	32433167	rs2395185	G	T	rs2395185	19122664	1.00E-16	NA	1.52	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
6	32433167	rs2395185	G	T	rs2395185	19915573	5.00E-22	NA	1.92	[1.68-2.19]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2395185-G	Research Support, Non-U.S. Gov't	G	NA
6	32509357	rs28772724	G	T	rs28772724	20848476	1.34E-08	Medically refractory ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis, refractory	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	NA	NA	NA	NA	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	G
6	32586854	rs9271366	G	A	rs9271366	23511034	1.00E-18	NA	2.1	[1.78-2.48]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9271366-G	Research Support, Non-U.S. Gov't	Comparative Study	A
6	32612397	rs6927022	A	G	rs6927022	23128233	5.00E-133	NA	1.44	[1.39-1.50]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6927022-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32800224	rs2228397	C	A	rs2228397	24837172	1.04E-05	NA	1.28	[1.15-1.43]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2228397-A	Research Support, Non-U.S. Gov't	G	TAP2
6	43795968	rs943072	G	T	rs943072	21297633	2.00E-10	NA	1.15	[1.08-1.23]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs943072-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	106522027	rs6911490	T	C	rs6911490	21297633	1.00E-08	NA	1.08	[1.03-1.13]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6911490-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	134661885	rs379977	A	C	rs379977	19915573	7.34E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
6	138006504	rs6920220	G	A	rs6920220	21297633	8.00E-17	NA	1.14	[1.09-1.20]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6920220-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	146824085	rs4543390	C	G	rs4543390	19915572	1.10E-06	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
7	2789880	rs798502	A	C	rs798502	21297633	3.00E-15	NA	1.13	[1.08-1.18]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs798502-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	2789880	rs798502	A	C	rs798502	23128233	6.00E-17	NA	1.13	[1.08-1.17]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs798502-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	18800413	rs11764116	G	T	rs11764116	20848476	2.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	T
7	27231762	rs4722672	C	T	rs4722672	23128233	2.00E-08	NA	1.09	[1.04-1.14]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4722672-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	81857893	rs929351	T	G	rs929351	20848476	8.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	T
7	98760504	rs7809799	G	A	rs7809799	20228798	9.00E-11	NA	1.56	[1.36-1.78]	1,043 German cases; 1,703 German controls	German(2746)	ALL(2746)	EUR(2746)	ALL(2746)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7809799-G	Research Support, Non-U.S. Gov't	A	NA
7	107453103	rs2108225	G	A	rs2108225	19915573	1.00E-07	NA	1.32	[1.19-1.47]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2108225-A	Research Support, Non-U.S. Gov't	A	NA
7	107479519	rs4730273	C	A	rs4730273	19122664	5.00E-06	NA	1.22	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
7	107480315	rs4380874	T	C	rs4380874	23128233	2.00E-26	NA	1.14	[1.10-1.18]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4380874-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	107484437	rs4730276	G	A	rs4730276	19122664	9.00E-06	NA	1.22	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	107492789	rs4510766	A	G	rs4510766	21297633	2.00E-16	NA	1.2	[1.15-1.26]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4510766-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	107495434	rs886774	G	A	rs886774	19915572	3.00E-08	NA	1.11	[1.03-1.19]	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs886774-G	Research Support, Non-U.S. Gov't	A	NA
7	107503441	rs4598195	A	C	rs4598195	19122664	1.00E-06	NA	1.23	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
7	107503441	rs4598195	A	C	rs4598195	20228799	8.00E-08	NA	1.09	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4598195-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
7	107580839	rs2158836	A	G	rs2158836	19122664	7.00E-06	NA	1.21	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2158836-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	128573967	rs4728142	G	A	rs4728142	21297633	2.00E-08	NA	1.07	[1.03-1.11]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4728142-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	128573967	rs4728142	G	A	rs4728142	23128233	4.00E-14	NA	1.1	[1.07-1.14]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4728142-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	128573967	rs4728142	G	A	rs4728142	23511034	3.35E-04	NA	1.38	[1.16-1.65]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4728142-A	Research Support, Non-U.S. Gov't	Comparative Study	G,A
9	4981602	rs10758669	C	A	rs10758669	20228799	1.00E-06	NA	1.22	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10758669-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
9	4981602	rs10758669	C	A	rs10758669	21297633	2.00E-25	NA	1.17	[1.12-1.21]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10758669-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	4981602	rs10758669	C	A	rs10758669	23511034	3.83E-05	NA	1.31	[1.15-1.49]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10758669-C	Research Support, Non-U.S. Gov't	Comparative Study	A
9	4981602	rs10758669	C	A	rs10758669	23511034	6.59E-05	NA	1.21	[1.10-1.34]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10758669-C	Research Support, Non-U.S. Gov't	Comparative Study	A
9	5213687	rs10975003	T	C	rs10975003	19915573	1.00E-06	NA	1.34	[1.18-1.51]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10975003-C	Research Support, Non-U.S. Gov't	C	NA
9	7209284	rs7020238	T	C	rs7020238	19915572	2.70E-05	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
9	85311147	rs668853	C	T	rs668853	19122664	2.00E-06	NA	1.2	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs668853-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
9	117553249	rs4246905	T	C	rs4246905	21297633	6.00E-12	NA	1.1	[1.05-1.15]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4246905-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	117605070	rs11554257	T	C	rs11554257	20848476	1.39E-06	Medically refractory ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis, refractory	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	NA	NA	NA	NA	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	T
9	139266405	rs10781499	G	A	rs10781499	21297633	3.00E-19	NA	1.12	[1.08-1.17]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs10781499-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	139266496	rs4077515	C	T	rs4077515	20228799	5.00E-08	NA	1.14	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4077515-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
9	139269338	rs10781500	C	T	rs10781500	19915572	7.00E-06	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	CARD9
10	29349286	rs1773842	G	A	rs1773842	19915573	9.32E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
10	35554054	rs12261843	T	G	rs12261843	21297633	7.00E-10	NA	1.07	[1.03-1.12]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs12261843-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	35554054	rs12261843	T	G	rs12261843	23511034	8.33E-04	NA	1.26	[1.10-1.44]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs12261843-G	Research Support, Non-U.S. Gov't	Comparative Study	T
10	101290301	rs6584283	T	C	rs6584283	19915572	2.00E-07	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
10	101290301	rs6584283	T	C	rs6584283	20228798	2.00E-06	NA	1.22	[1.12-1.32]	1,043 German cases; 1,703 German controls	German(2746)	ALL(2746)	EUR(2746)	ALL(2746)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6584283-T	Research Support, Non-U.S. Gov't	C	NA
10	101290301	rs6584283	T	C	rs6584283	21297633	8.00E-21	NA	1.21	[1.16-1.26]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6584283-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	101291593	rs11190140	T	C	rs11190140	20228799	1.00E-08	NA	1.2	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11190140-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
11	1874072	rs907611	G	A	rs907611	21297633	1.00E-10	NA	1.08	[1.03-1.13]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs907611-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	13925559	rs12271425	G	C	rs12271425	19915572	2.10E-05	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
11	24356464	rs7950920	G	A	rs7950920	19915573	4.32E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	A	NA
11	76299194	rs2155219	G	T	rs2155219	21297633	5.00E-16	NA	1.13	[1.08-1.17]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2155219-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	96023427	rs483905	G	A	rs483905	23128233	1.00E-08	NA	1.06	[1.02-1.10]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs483905-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	114386830	rs561722	C	T	rs561722	23128233	5.00E-17	NA	1.12	[1.08-1.16]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs561722-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	114431956	rs678170	A	G	rs678170	21297633	5.00E-14	NA	1.09	[1.05-1.14]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs678170-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	21976428	rs4148677	C	T	rs4148677	24837172	2.26E-05	NA	1.32	[1.10-1.58]	603 North Indian ancestry cases; 622 North Indian ancestry controls	North Indian(1225)	ALL(1225)	SAN(1225)	ALL(1225)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4148677-G	Research Support, Non-U.S. Gov't	G	ABCC9
12	68500075	rs7134599	G	A	rs7134599	21297633	1.00E-16	NA	1.19	[1.19-1.24]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7134599-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	68504592	rs1558744	G	A	rs1558744	19122664	3.00E-12	NA	1.35	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1558744-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	68504592	rs1558744	G	A	rs1558744	20228799	4.00E-12	NA	1.16	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1558744-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	68504592	rs1558744	G	A	rs1558744	20848476	9.03E-05	Medically refractory ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis, refractory	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	NA	NA	NA	NA	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	A
12	68596661	rs2870946	T	C	rs2870946	19122664	5.00E-07	NA	1.54	NA	1,022 cases; 2,503 controls	NOPOP(3525)	ALL(3525)	NOPOP(3525)	ALL(3525)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2870946-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
13	27531267	rs17085007	T	C	rs17085007	19915573	7.00E-08	NA	1.35	[1.21-1.51]	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs17085007-C	Research Support, Non-U.S. Gov't	T	NA
13	27531267	rs17085007	T	C	rs17085007	21297633	1.00E-16	NA	1.16	[1.10-1.21]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs17085007-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	27531267	rs17085007	T	C	rs17085007	23511034	3.00E-07	NA	1.37	[1.22-1.55]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs17085007-C	Research Support, Non-U.S. Gov't	Comparative Study	T
13	27531267	rs17085007	T	C	rs17085007	23511034	8.00E-06	NA	1.4	[1.21-1.63]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs17085007-C	Research Support, Non-U.S. Gov't	Comparative Study	T
13	27533642	rs9553939	G	A	rs9553939	19915573	4.60E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
13	27537873	rs6491170	T	C	rs6491170	19915573	8.11E-06	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	C	NA
13	27542276	rs3897233	C	A	rs3897233	19915572	1.20E-06	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
13	27543757	rs6650264	C	T	rs6650264	19915573	4.00E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
13	40505510	rs9548988	C	T	rs9548988	19915572	3.00E-07	NA	1.1	[1.03-1.19]	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs9548988-T	Research Support, Non-U.S. Gov't	T	NA
13	41013977	rs941823	T	C	rs941823	21297633	4.00E-12	NA	1.12	[1.07-1.17]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs941823-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	79550934	rs7319358	C	T	rs7319358	20848476	3.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	C
14	29132877	rs1956388	G	A	rs1956388	20848476	2.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	T
14	75734471	rs8004059	G	A	rs8004059	19915573	9.61E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
14	75747118	rs1063169	G	T	rs1063169	23511034	1.20E-05	NA	1.27	[1.14-1.41]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
14	77138110	rs17104722	G	C	rs17104722	19915572	3.90E-06	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
14	82669795	rs9323719	C	T	rs9323719	19915573	1.37E-06	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
15	41563950	rs28374715	A	G	rs28374715	23128233	2.00E-08	NA	1.08	[1.04-1.13]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs28374715-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	10975311	rs4781011	T	G	rs4781011	20228799	3.00E-06	NA	1.12	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs4781011-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
16	18023977	rs1428103	C	T	rs1428103	19915572	6.00E-06	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
16	20030832	rs2764742	C	T	rs2764742	19915572	6.80E-07	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	NA
16	30482494	rs11150589	T	C	rs11150589	23128233	6.00E-10	NA	1.09	[1.05-1.13]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs11150589-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	68573945	rs1182968	C	T	rs1182968	20848476	5.66E-04	Medically refractory ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis, refractory	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	NA	NA	NA	NA	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	G
16	68591230	rs1728785	A	C	rs1728785	19915572	3.00E-08	NA	1.17	[1.07-1.27]	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1728785-G	Research Support, Non-U.S. Gov't	C	ZFP90
16	68591230	rs1728785	A	C	rs1728785	23128233	4.00E-08	NA	1.08	[1.03-1.12]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1728785-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	68674788	rs6499188	G	A	rs6499188	21297633	4.00E-08	NA	1.14	[1.09-1.20]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6499188-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	81959952	rs7201045	A	G	rs7201045	19915573	9.02E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	PLCG2
16	81960200	rs8063604	A	G	rs8063604	19915573	2.77E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	A	PLCG2
16	81960365	rs12446596	C	T	rs12446596	19915573	2.45E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	T	PLCG2
16	86009740	rs16940186	T	C	rs16940186	23511034	4.00E-10	NA	1.56	[1.36-1.80]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs16940186-G	Research Support, Non-U.S. Gov't	Comparative Study	T
16	86014241	rs16940202	T	C	rs16940202	21297633	6.00E-19	NA	1.15	[1.10-1.21]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs16940202-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	86014241	rs16940202	T	C	rs16940202	23511034	3.00E-09	NA	1.52	[1.32-1.74]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs16940202-C	Research Support, Non-U.S. Gov't	Comparative Study	C
16	86827339	rs13337840	A	G	rs13337840	19915572	9.00E-07	NA	NA	NA	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	G	NA
17	38040763	rs2872507	G	A	rs2872507	21297633	5.00E-11	NA	1.15	[1.10-1.19]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2872507-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	38040763	rs2872507	G	A	rs2872507	23511034	6.04E-04	NA	1.26	[1.10-1.45]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2872507-A	Research Support, Non-U.S. Gov't	Comparative Study	G
17	38051348	rs8067378	A	G	rs8067378	20228799	1.00E-07	NA	1.12	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs8067378-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
17	38062196	rs2305480	G	A	rs2305480	20228799	3.00E-08	NA	1.15	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2305480-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
17	70641698	rs7210086	A	C	rs7210086	23128233	2.00E-09	NA	1.11	[1.06-1.16]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs7210086-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
19	47123783	rs1126510	A	G	rs1126510	23128233	2.00E-09	NA	1.08	[1.04-1.11]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1126510-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	31718653	rs6059101	C	T	rs6059101	20848476	4.00E-06	Ulcerative colitis	NA	NA	861 British cases; 2601 European ancestry non-IBD controls	British(861)	European(2601)	ALL(3462)	EUR(3462)	ALL(3462)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, N.I.H., Extramural	C
20	33799280	rs6088765	T	G	rs6088765	23128233	2.00E-08	NA	1.08	[1.04-1.12]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6088765-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	43065028	rs6017342	A	C	rs6017342	19915572	9.00E-17	NA	1.17	[1.09-1.26]	2,361 European ancestry cases; 5,417 European ancestry controls	European(7778)	ALL(7778)	EUR(7778)	ALL(7778)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6017342-C	Research Support, Non-U.S. Gov't	C	NA
20	43065028	rs6017342	A	C	rs6017342	21297633	1.00E-20	NA	1.2	[1.15-1.26]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6017342-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	43065028	rs6017342	A	C	rs6017342	23128233	1.00E-43	NA	1.23	[1.19-1.27]	Up to 12,924 European ancestry cases; up to 21,442 European ancestry controls	European(34366)	ALL(34366)	EUR(34366)	ALL(34366)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs6017342-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	62327582	rs2297441	G	A	rs2297441	21297633	2.00E-10	NA	1.09	[1.04-1.15]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2297441-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
21	16805220	rs1736135	T	C	rs1736135	20228799	2.00E-07	NA	1.2	NA	2,693 European descent cases; 6,791 European descent controls	European(9484)	ALL(9484)	EUR(9484)	ALL(9484)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1736135-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
21	16817051	rs1297265	A	G	rs1297265	21297633	7.00E-13	NA	1.11	[1.06-1.15]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs1297265-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
21	40465534	rs2836878	G	A	rs2836878	21297633	2.00E-22	NA	1.25	[1.20-1.32]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2836878-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
21	41986768	rs2837751	C	A	rs2837751	19915573	2.99E-05	NA	NA	NA	376 Japanese cases; 934 Japanese controls	Japanese(1310)	ALL(1310)	ASN(1310)	ALL(1310)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	NA	Research Support, Non-U.S. Gov't	A	DSCAM
21	45615023	rs2838519	G	A	rs2838519	21297633	6.00E-11	NA	1.14	[1.05-1.22]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs2838519-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
22	21939675	rs5754217	G	T	rs5754217	23511034	9.84E-07	NA	1.26	[1.15-1.37]	388 Korean ancestry cases; 739 Korean ancestry controls	Korean(1127)	ALL(1127)	ASN(1127)	ALL(1127)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs5754217-T	Research Support, Non-U.S. Gov't	Comparative Study	T
22	50435480	rs5771069	A	G	rs5771069	20228798	4.00E-08	NA	1.17	[1.11-1.25]	1,043 German cases; 1,703 German controls	German(2746)	ALL(2746)	EUR(2746)	ALL(2746)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs5771069-G	Research Support, Non-U.S. Gov't	G	IL17REL
22	50435480	rs5771069	A	G	rs5771069	21297633	2.00E-07	NA	1.11	[1.07-1.16]	6,687 European ancestry cases; 19,718 European ancestry controls	European(26405)	ALL(26405)	EUR(26405)	ALL(26405)	Ulcerative colitis	HPOID:0100279	Ulcerative colitis	DOID:8577	ulcerative colitis	D003093	Colitis, Ulcerative	EFOID:0000729	ulcerative colitis	Ulcerative colitis	rs5771069-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	177
Disease	ulcerative colitis
Case	(Waiting for update.)